| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Molecular Recognition |
| Session Leader: Clemens Richert |
| Welcome and Introductory remarks |
| Melissa Starovasnik
Peptide Inhibitors of IgE: Convergent Recognition of the High-Affinity IgE Receptor |
| Nat Finney
Fluorescent chemosensor based on conformational restriction: a new, general approach to visualizing molecular recognition |
| Peter Dervan
Design of Artificial Transcription Factors |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Conference Photograph |
| 9:00 am - 12:30 pm | Frontiers of Small Molecule Action |
| Session Leader: Kurt Deshayes |
| Tim Clackson
Dimerizers and disaggregators: using small molecules to control protein-protein interactions |
| Kevin Judice
Vancomycin Dimers--Expect the Unexpected |
| Coffee break |
| Jonathon Sessler
Oligopyrrole-based Anion Binding Agents |
| Andrew Braisted
Site Directed-Drug Discovery at Signaling Interfaces |
| Poster Talk I: Debbie Mohler
Radical-Based Functionalization of Proteins |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Nucleic Acids |
| Session Leader: Terry Sheppard |
| Scott Singleton
Nucleic Acid Dynamics in Genomic Repair and Recombination |
| Anne Baranger
Recognition of Single-Stranded RNA by Proteins |
| Karin Musier-Forsyth
Nucleic Acid Rearrangements in HIV
|
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Engineering & design |
| Session Leader: Paul Baures |
| Lars Baltzer
The introduction of catalytic functions into young and old proteins by rational design |
| Jean Chmielewski
Small Molecule Inhibitors of Protein-Protein Interactions: HIV Enzymes |
| Coffee break |
| Samuel Stupp
Self Assembly of Artificial Extracellular Matrices |
| Pehr Harbury
Automated Design of Specificity in Molecular
Recognition |
| Poster Talk II: Krishna Kumar
De Novo Design of Membrane Proteins |
| Poster Talk III: Rick Wagner
Designing Protein Dimerizers: The Importance of Ligand Conformational
Equilibria
|
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Combinatorial Approaches |
| Session Leader: Thomas VonGeldern |
| Mark Murcko
Parallel Drug Discovery Across Gene Families
|
| Alexey Eliseev
Dynamic Combinatorial Chemistry |
| Matt Shair
Using Biomimetic Synthesis to Explore Cell Biology |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Enzyme Catalysis |
| Session Leader: Tamara Hendrickson |
| Jochen Reinstein
From ATP hydrolysis to protein folding: Mechanisms of molecular Chaperones |
| Jack Kirsch
Stability, evolution and directed evolution of aspartate
aminotransferase |
| Coffee break |
| Arieh Warshel
Using Computer Simulations to Validate/Eliminate catalytic proposals |
| Steve Benkovic
A Perspective on Biological Catalysis |
| Poster Talk IV: Suzy Shuker
HTLV-I Protease: Mutations, Activity and Specificity
|
| Poster Talk V: Chris Seto
Alpha-Ketoacid Based Inhibitors for Protein Tyrosine Phosphatases |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Evolution of Function |
| Session Leader: Nicola Pohl |
| Phillip Patten
Protein evolution, R.A. Fisher style |
| Ikeo Fujii
In vitro Evolution of Biofunctional Molecules in Phage-displayed Combinatorial
Libraries |
| Don Hilvert
Searching sequence space for protein catalysts |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | New Methods/Spectroscopic Approaches |
| Session Leader: Robert Ben |
| Peter Tonge
Red light, green light: fluorescent proteins stop and go |
| Debra Leckband
Using force measurements to dissect complex protein interactions |
| Coffee break |
| Neil Kelleher
Development of a General Platform for Robust Detection of Eukaryotic Post-translational Modifications: Separation Science, FT Mass Spectrometry, and Informatics |
| Itaru Hamachi
Modulation of Molecular Recognition on a Protein Surface |
| Poster Talk VI: Wojciech Stec
New Method of Assignment of Absolute Configuration at Phosphorus in Isotopomeric P-Chiral Adenosine 5'-O-[18O]-Phosphorothioates |
| Poster Talk VII: David Berkowitz
An In Situ Enzymatic Screening (ISES) Approach to Catalyst Discovery |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Bioorganic Chemistry: A Crossroads of Ideas |
| Session Leader: Babak Borhan |
| Business Meeting |
| Ron Breslow
The Two Faces of Bioorganic Chemistry |
| Dale Poulter
Chrysanthemyl Diphosphate Synthase. Lessons in Chemistry from Biology |
| Peter Schultz
New Opportunities at the Interface of Chemistry and Biology |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
