SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | SINGLE MOLECULES AND BIOPHYSICAL METHODS |
| Discussion Leader: Claudio Chuaqui (AstraZeneca) |
7:35 pm - 8:05 pm | Maria Pellegrini (Biogen Idec)
"Weak and Weaker: NMR Methods for Characterization, Validation, and Promotion of Early Lead Candidates" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Robert Singer (Yeshiva)
"Watching Single mRNAs" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Sunney Xie (Harvard)
"Actions on DNA: Lessons from Real-Time Movies, In Vitro and In Vivo" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | MODEL SYSTEMS |
| Discussion Leader: Sergey Savinov (Purdue) |
9:00 am - 9:30 am | Matthew Francis (Berkeley)
"New Chemical Reactions for Site-Selective Protein Modification" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Indraneel Ghosh (Arizona)
"Sequence Enabled Reassembly of Proteins for Seeing Native DNA" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Jacqueline Barton (Caltech)
"DNA Charge Transport: Oxidative Damage and Repair" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | William DeGrado (Penn)
"De Novo Design of Proteins, Peptides, and Peptide Mimetics" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Poster Talk I: Bobby Arora (NYU) "Structure and Function in Hydrogen Bond Surrogate Based Helices" |
12:15 pm - 12:30 pm | Poster Talk II: Jeff Keillor (Montreal) "Development of a Dimaleimide-Based Protein Labelling Method" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MOLECULAR AND CELLULAR PROBES |
| Discussion Leader: Jeffrey Bode (Santa Barbara) |
7:30 pm - 8:00 pm | Gregor Zlokarnik (Vertex)
"Creativity in design or validation? Enabling techniques versus single-use probes" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Paul Hergenrother (Illinois)
"Small Molecules as Tools to Identify Novel Anti-Cancer Targets" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Milan Mrksich (Chicago)
"Tailored Substrates for Cell Adhesion" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DRUG DESIGN AND DISCOVERY |
| Discussion Leader: John Starrett (Bristol-Meyers Squibb) |
9:00 am - 9:30 am | Jay Grobler (Merck)
"Directed Discovery of New Antiretroviral Agents" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Stewart Fisher (AstraZeneca)
"Murl as a Druggable Target" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Andrea Cochran (Genentech)
"Inhibitors and Mechanism in the Aurora Kinase Family" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Timothy Willson (GlaxoSmithKline)
"Lipids as Ligands for Orphan Nuclear Receptors" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Poster Talk III: Rami Hannoush (Genentech)
"Reversible Small Molecule-Induced Fragmentation of the Mammalian Golgi Apparatus" |
12:15 pm - 12:30 pm | Poster Talk IV: James Chen (Stanford)
"Chemical Tools for the Spatiotemporal Control of Zebrafish Gene Expression" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TRANSCRIPTION FACTORS AND DNA REPAIR |
| Discussion Leader: Orlando Schaerer (Stony Brook) |
7:30 pm - 8:00 pm | John Koh (Delaware)
"Chemical Rescue of Nuclear Receptor Mutants" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | John Essigmann (MIT)
"Design of DNA Damaging Agents that Hijack Transcription Factors and Block DNA Repair" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Gregory Verdine (Harvard)
"Finding a Needle in a Haystack: The Challenge of Lesion Searching by DNA Glycosylases" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | VISUALIZING CELLULAR BIOLOGY |
| Discussion Leader: James Chen (Stanford) |
9:00 am - 9:30 am | Jennifer Lippincott-Schwartz (NIH)
"Use of photoactivatable fluorescent proteins for studying protein and organelle dynamics in living cells" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Kai Johnsson (Lausanne)
"Chemical Approaches for Visualizing Protein Function" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Peter Sorger (Harvard)
"Systems-Level Analysis of Anti-ErbB Therapeutics" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Tom Kirchhausen (Harvard)
"Chemical Biology of Membrane Traffic" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FRONTIERS IN ENZYMOLOGY |
| Discussion Leader: Lizbeth Hedstrom (Brandeis) |
7:30 pm - 8:00 pm | Robert Copeland (GlaxoSmithKline)
"Drug-Target Residence Time, A Different Perspective on Compound Optimization" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Donald Hilvert (ETHZ)
"Molecular Diversity and Catalysis" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Stephen Benkovic (Penn State)
"Perspectives on Biological Catalysis" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EMERGING AREAS IN CHEMICAL BIOLOGY |
| Discussion Leader: Jason Gestwicki (Michigan) |
9:00 am - 9:30 am | Helen Blackwell (Wisconsin-Madison)
"Synthetic Ligands that Disrupt Bacterial Quorum Sensing Pathways and Outcomes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Nicole Sampson (Stony Brook)
"ROMPing with ADAM: Polymer Probes of Fertilization" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | James Wells (UCSF)
"Site-Directed Chemical Approaches to Caspase Signaling" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Gerald Crabtree (Stanford)
"Designing small molecules to make and break protein-protein interactions" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Poster Talk V: Jennifer Kohler (Stanford)
"Cooperation among glycosylation enzymes" |
12:15 pm - 12:30 pm | Poster Talk VI: Elizabeth Boon (Stony Brook)
"Determining a Molecular Basis for NO Signaling in Bacterial Biofilms" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW PARADIGMS IN BIOORGANIC AND MEDICINAL CHEMISTRY |
| Discussion Leader: Brian Blagg (Kansas) |
7:30 pm - 8:00 pm | Dale Boger (Scripps)
"Chemistry at the Chemistry-Biology Interface" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Andrew Hamilton (Yale)
"Synthetic Approaches to Disrupting Protein-Protein Interactions" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | François Diederich (ETHZ)
"Structure-Based Design of Non-Peptidic Enzyme Inhibitors: New Targets in the Treatment of Infectious Diseases" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |