SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | ENZYME INHIBITION |
| Discussion Leader: Peter Andreana (Wayne State University) |
7:35 pm - 8:05 pm | Charly Craik (UCSF)
"Inhibiting the Uninhibitable: Proteases in Infectious Disease and Cancer" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Matt Bogyo (Stanford University)
"Using Small Molecule Probes to Image Protease Activity" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Vern Schramm (Albert Einstein College of Medicine)
"Transition States and Inhibitors from Kinetic Isotope Effects" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | ENABLING NEW METHODS I |
| Discussion Leader: Qing Lin (SUNY Buffalo) |
9:00 am - 9:30 am | Andy Griffiths (Universite Louis Pasteur, Strasbourg, France)
"Miniaturising Biology and Chemistry in Droplets" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Stephen Kent (University of Chicago)
"Through the Looking Glass a New World of Proteins Enabled by Chemistry" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Sachdev Sidhu (University of Toronto)
"Large-scale Analysis of Natural and Synthetic PDZ Domains" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Rustem Ismagilov (University of Chicago)
"Using Microfluidics to Control Chemical Space" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short Talk: Jason Gestwicki (University of Michigan)
"Allosteric Modulators of Heat Shock Protein 70" |
12:15 pm - 12:30 pm | Short Talk: Amy Barrios (University of Utah)
"Chemical Probes put Phosphotyrosine-dependent Cellular Signaling in the Spotlight" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ENABLING NEW METHODS II |
| Discussion Leader: Dennis Bong (Ohio State University) |
7:30 pm - 8:00 pm | Paul Thompson (University of South Carolina)
"Haloacetamidine Based Inactivators and Activity Based Protein Profiling Reagents for Protein Arginine Deiminase 4: A Novel Target for the Treatment of Rheumatoid Arthritis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Lara Mahal (University of Texas)
"Analyzing the Dynamic Glycome" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Corey (University of Texas Southwestern Medical Center)
"Controlling Gene Expression with Small RNAs that Target Promoters" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | REGULATION OF CELLULAR PROCESSES |
| Discussion Leader: Ulrike Eggert (Dana Farber Cancer Institute/Harvard Medical School) |
9:00 am - 9:30 am | Peter Schultz (Scripps Research Institute)
"A Chemical Approach to Stem Cell Biology" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Deborah Hung (Harvard Medical School/Broad Institute)
"Small Molecule Probes of Bacterial Pathogenesis" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Jean Bemis (Sirtris Pharmaceuticals)
"The Design and Evaluation of Novel Small Molecule Sirtuin Modulators" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Herbert Waldmann (Max Planck Institute, Dortmund, Germany)
"The Dynamic Ras Cycle" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short Talk: Christian Melander (North Carolina State University)
"Small Molecule Control of Bacterial Biofilms" |
12:15 pm - 12:30 pm | Short Talk: Vicki Lai (GlaxoSmithKline)
"Aurora Kinase Inhibitors for Clinical Development: Working Towards Physiological Relevance" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | BIOMATERIALS |
| Discussion Leader: Ivan Dmochowski (University of Pennsylvania) |
7:30 pm - 8:00 pm | Heather Maynard (UCLA)
"Synthesis of Amino Acid Initiators for Polymerization and in situ Biohybrid Formation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Hao Yan (Arizona State University)
"Designer DNA Architectures for Nanobiotechnology" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Arikha Moses (TyRX Pharma)
"Optimized Resorbable Polymers for Dual-drug Antimicrobial Products" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NATURAL PRODUCTS BIOSYNTHESIS |
| Discussion Leader: Clay Chia Chun Wang (University of Southern California) |
9:00 am - 9:30 am | Susan Roberts (UMass Amherst)
"Terpenoid Engineering: Paclitaxel Production in Plant Cell Culture" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Sarah O'Connor (MIT)
"Alkaloid Biosynthesis" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Sheo Singh (Merck)
"Discovery and Characterization of Platensimycin and Platencin" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Steve Bruner (Boston College)
"Mechanism and Structure of Non-ribosomal Peptide Natural Product Biosynthetic Pathways" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short Talk: Martin Burke (University of Illinois)
"Synthesis-Enabled Studies of the Amphotericin B Ion Channel" |
12:15 pm - 12:30 pm | Short Talk: Richard Roberts (USC)
"High Affinity Peptide Design via Cyclic mRNA Display" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | SMALL MOLECULES IN CELL BIOLOGY |
| Discussion Leader: Jennifer Ottesen (Ohio State University) |
7:30 pm - 8:00 pm | Jack Taunton (UCSF)
"Defining the Druggable Cysteinome" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Tarun Kapoor (Rockefeller University)
"Spatial Organization of Signaling During Cell Division" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Kip Guy (St. Jude Children's Research Hospital)
"Functional Antagonism of Thyroid Hormone Signaling" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NUCLEIC ACIDS |
| Discussion Leader: Sarah Delaney (Brown University) |
9:00 am - 9:30 am | Eric Kool (Stanford University)
"The Chemistry of Information Transfer in Natural and Designed Genetic Systems" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Patrick Lam (Bristol-Myers Squibb)
"Molecular Recognition of Apixaban/Factor Xa and Chan-Lam Coupling Reaction" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Shana Sturla (University of Minnesota)
"Chemical Probes of Genotoxicity" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Shyam Rele (Calando)
"Cyclodextrin-containing Polymer-mediated Delivery of siRNA" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short Talk: Jumi Shin (University of Toronto)
"Minimalist bHLHZ-bZIP Hybrids Target the E-box DNA Site" |
12:15 pm - 12:30 pm | Short Talk: Alexander Deiters (North Carolina State University)
"Light-regulation of Nucleic Acids" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FRONTIERS OF BIOORGANIC CHEMISTRY |
| Discussion Leader: Jin Montclare (Polytechnic
University / SUNY Downstate Medical Center) |
7:30 pm - 8:00 pm | Anna Mapp (University of Michigan)
"Small Molecule Control of Protein Complex Assembly" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Steve Elmore (Abbott)
"Targeting Bcl-2 Family Protein-Protein Interactions |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Kevan Shokat (UCSF)
"Design of Small Molecule Inhibitors in the RTK-PI3K-mTOR Pathway" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |