SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:30 pm - 9:30 pm | VIRAL SCOURGES: ADVANCING DRUG DESIGN |
| Discussion Leader: Alexey Lugovsky (BiogenIdec) |
7:35 pm - 8:05 pm | Ann Kwong (Vertex) "Reducing Risk in Drug Discovery: Preclinical Development of the Hepatitis C Virus Protease Inhibitor Telaprevir (VX-950)" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Diane Joseph-McCarthy (AstraZeneca) "Fragment Screening for Drug Discovery" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Carlos Simmerling (Stony Brook) "Computational studies of HIV-1 protease, a model system for the role of receptor dynamics in ligand binding and drug resistance" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | BACTERIAL TREASURE TROVES: MAKING THE GOLD |
| Discussion Leader: Edward Driggers (Agios) |
9:00 am - 9:30 am | Joseph Noel (Salk) "Peeling Back the Layers of Time: Reconstructing the Evolutionary History of Nature's Biosynthetic Toolbox" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Poster Talk #1: Rebecca Butcher (Harvard Med) "Small-molecule Pheromones Controlling C. elegans Development and their Biosynthesis" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | David Cane (Brown) "Nature's Dirty Secrets: Genome Mining in Streptomyces" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Brian Bachman (Vanderbilt) "Dissecting and Directing Biosynthesis of Drugs by Bacteria" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #2: Clay Wang (USC) "Mining the Fungal Secondary Metabolome Using Genetic Tools" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #3: Emily Weinert (UC Berkeley) "Controlling Oxygen Affinity in Tt H-NOX: Progress Towards a Potential Blood Substitute" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW MATERIALS: BLOOD, SWEAT & TEARS |
| Discussion Leader: Yomi Oyelere (Georgia Tech) |
7:30 pm - 8:00 pm | Jerry Yang (UCSD) "Designing Functional Molecular Assemblies on Biological Surfaces" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Gregory Tew (U Mass Amherst) "Antimicrobial and Cell Penetrating Peptide Mimics From Simple Scaffolds: New Insight Into Molecule-Membrane Interactions" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Ron Kluger (Toronto) "Keeping Artificial Blood Flowing: Enhanced Nitrite Reductase Activity of Chemically Altered Hemoglobins" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MOLECULAR DIAMONDS: BUILDING MULTIFACETED PEPTIDES |
| Discussion Leader: Isaac Carrico (Stony Brook) |
9:00 am - 9:30 am | Dehua Pei (Ohio State) "Combinatorial Chemistry: From Cell Signaling to Catalyst Development" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Poster Talk #4: Joshua Kritzer (MIT/Tufts) "Rapid chemical genetics using cyclic peptides: Application to cellular and animal models of Parkinson's disease" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Felicia Etzkorn (Virginia Tech) "Conformational Regulation of the Cell Cycle: Cdc2 Kinase is Specific for Ser-trans-Pro Substrate" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | John Robinson (Zurich) "Protein Epitope Mimetics in Chemical Biology" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Helma Wennemers (Basel) "Bioinspired Chemistry Using the Many Faces of Peptides" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TRACKING CANCER AND PUTTING ON THE BRAKES |
| Discussion Leader: Zev Gartner (UCSF) |
7:30 pm - 8:00 pm | Lisa Shewchuk (GSK) "Discovery of an Inhibitor of IGF1R Activation: Implications for Cellular Potency and Selectivity over Insulin Receptor" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Patrick Zarrinkar (Ambit) "Unlocking Value in Chemical Libraries: Inhibitor Discovery Driven by High Throughput Kinase Profiling" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Mark Mulvihill (OSI) "The Discovery of OSI-906: A Novel, Potent, Orally Bioavailable Imidazopyrazine-derived Insulin-Like Growth Factor-I Receptor (IGF-1R) Inhibitor with Antitumor Activity" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BACTERIAL SCOURGES: TRYING TO OUTSMART THEM |
| Discussion Leader: Danica Fujimori (UCSF) |
9:00 am - 9:30 am | Eric Brown (McMaster) "Chemical Genomics: Charting Chemical-Genetic Interactions in Bacteria" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Poster Talk #5: Samantha Shanley (Oxford) "A ‘GlycoPore’ for Bacterial Sensing" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Grant Walkup (AstraZeneca) "Novel DNA Gyrase Inhibitors: Fragment-Based NMR Screening to Antibacterial Agents" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Carl Nathan (Cornell-Weill) "Chemical Biology of Non-Replicating Mycobacterium Tuberculosis" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #6: Herman Sintim (U Maryland) "New Isothermal Strategies for the Detection Of Disease Biomarkers - from Junction Probes to DNAzymes" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #7: Deborah Rothman (Novartis) "Novel Targets for Disease Pathways: A Chemical Genetics Approach" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | MONITORING METABOLITES: NEEDLE IN THE HAYSTACK |
| Discussion Leader: Ranabir Sinha Roy (Merck) |
7:30 pm - 8:00 pm | Amy Palmer (Colorado) "Tools for Real-Time Imaging of Host-Pathogen Interactions" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Michelle Reyzer (Vanderbilt) "MALDI Mass Spectrometry: A New Tool For Metabolite Imaging" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Peter Beal (Davis) "The Chemistry of RNA Recoding by Adenosine Deamination" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | INVASION OF MOLECULAR SYNTHESIS: TO ACTIVATORS & BEYOND! |
| Discussion Leader: Rami Hannoush (Genentech) |
9:00 am - 9:30 am | Jim Hartman (Cytokinetics) "Get Your Motors Runnin’: Activating Sarcomeres with Small Molecules" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Poster Talk #8: Shin Mizuakmi (Osaka) "Development of MRI Probes for Detecting Biological Signals" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Sergey Kozmin (Chicago) "Practical Organic Synthesis to Unravel Chemical Biology of Complex Natural Products" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Qing Lin (Buffalo) "Photoinducible Bioorthogonal Chemistry: A New Tool for Chemical Biology" |
11:40am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Orion Jankowski (Edison Pharma) "Cellular Redox Signaling in Drug Discovery" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FRONTIERS IN CHEMICAL BIOLOGY |
| Discussion Leader: Tamara Hendrickson (Wayne State) |
7:30 pm - 8:00 pm | Barbara Imperiali (MIT) "Asparagine-linked Protein Glycosylation: Pathways and Processes" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Joanna Fowler (Brookhaven National Lab) "Imaging Addiction in the Human Brain" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Carolyn Bertozzi (UC Berkeley) "Interrogating the Glycome with Chemical Probes" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |