SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | NEW PERSPECTIVES IN BIOLOGICAL CATALYSIS |
| Discussion Leader: Irene Lee (Case Western Reserve University) |
7:40 pm - 8:10 pm | Squire Booker (Pennsylvania State University) "C-H Bond Activation: Doing it in the Absence of Oxygen" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Poster Talk #1: John Richard (University of Buffalo) "A Role for Phosphate Gripper Loops in Enzymatic Catalysis" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Joanne Stubbe (Massachusetts Institute of Technology) "Biosynthesis of Metallo-cofactors in vitro and in vivo" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | NOVEL METHODS AND CHEMICAL TOOLS |
| Discussion Leader: Erin Carlson (Indiana University) |
9:00 am - 9:30 am | Gang-yu Liu (University of California, Davis) "Design and Production of Architectures for Regulation of Cellular Signaling Processes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Kate Carroll (University of Michigan) "Painting the Cysteine Chapel: New Tools to Probe Redox Signal Transduction" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Alan Saghatelian (Harvard University) "Peptidomics Approaches to Endogenous Peptide Metabolism" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Kay Ahn (Pfizer) "Discovery of Highly Selective Fatty Acid Amide Hydrolase (FAAH) Inhibitors for the Treatment of Inflammatory Pain" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #2: Junko Ohkanda (Osaka University) "Module Assembly for Disruption and Detection of Protein-Protein Interactions" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | BACTERIA: FRIEND OR FOE |
| Discussion Leader: David Ehmann (AstraZeneca) |
7:30 pm - 8:00 pm | Michelle Chang (University of California, Berkeley) "Building New Chemical Function in E. coli" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Douglas Weibel (University of Wisconsin, Madison) "A Chemical Biological Approach to Studying Spatial Organization in Bacteria" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Shahriar Mobashery (University of Notre Dame) "Bacterial Cell Wall Turnover" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DNA REPAIR AND THERAPEUTICS |
| Discussion Leader: Penny Beuning (Northeastern University) |
9:00 am - 9:30 am | Amanda Bryant-Friedrich (University of Toledo) "The Interplay of Oxidative Damage and Protein-DNA Interactions" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Sheila David (University of California, Davis) "The Good, the Bad and the Damaged: Mediation of Oxidative DNA Damage by Base Excision Repair Glycosylases" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Theresa Reineke (Virginia Technological University) "Glycopolymer Carriers for Nucleic Acid Delivery and Diagnostic Imaging" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Poster Talk #3: Nathan Luedtke (University of Zurich) "Structure-Selective Fluorescent Probes for Nucleic Acids" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #4: Peter Andreana (Wayne State University) "Targeting Cellular Immunity with Entirely Carbohydrate-based Constructs" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #5: Jeffery Gildersleeve (National Cancer Institute) "Glycan Arrays and Cancer Vaccines: Partners for Life" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MOLECULAR SWITCHES |
| Discussion Leader: Jean-Paul Desaulniers (University of Ontario Institute of Technology) |
7:30 pm - 8:00 pm | Beatrix Suess (Goethe-Universität Frankfurt am Main) "Engineered Riboswitches: An Alternative Means for Conditional Gene Expression" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Justin Gallivan (Emory University) "Reprogramming Bacteria with Small Molecules and RNA" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Dirk Trauner (Ludwig-Maximilians-Universität München) "Controlling Neural Activity with Molecular Switches" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | REMODELING PROTEIN FUNCTION |
| Discussion Leader: Minkui Luo (Memorial Sloan-Kettering Cancer Center) |
9:00 am - 9:30 am | Jennifer Ottesen (The Ohio State University) "Chemical Tools to Probe Histone Modification in the Nucleosome Core" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Hening Lin (Cornell University) "The Enzymatic Activity of Sirtuins: Beyond NAD-Dependent Deacetylation" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Carol Fierke (University of Michigan) "Mechanism and Regulation of Metal-Dependent Deacetylases" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Poster Talk #6: Michael Acker (Harvard University) "Biosynthesis of the Thiocillin Family of Thiopeptides: A Mutasynthetic Approach" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #7: Richard Gantt (University of Wisconsin) "Exploiting Glycosyltransferase Reversibility for Nucleotide Diphosphate Sugar Synthesis" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #8: Emma Doud (Harvard University) "TIM-Barrel Prenyltransferases in Bacteria" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | CHEMICAL BIOLOGY OF DISEASE |
| Discussion Leader: Rami Hannoush (Genentech, Inc.) |
7:30 pm - 8:00 pm | Stephanie Leavitt (Gilead Sciences) "The Combined Use of Label-free Binding Technologies During Lead Identification, Validation, and Optimization" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Thomas Hermann (University of California, San Diego) "Targeting RNA with Synthetic Ligands of Natural Product-like Complexity" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Michael Gelb (University of Washington, Seattle) "Bioorganic Chemistry of Saving Babies From Devastating Enzyme Deficiency Diseases" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DESIGN, DEVELOP, DISCOVER |
| Discussion Leader: Samy Meroueh (Indiana University School of Medicine) |
9:00 am - 9:30 am | Robert Lazarus (Genentech, Inc.) "Pseudo-proteases in Biology and Cancer Signaling Pathways" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Dustin Maly (University of Washington, Seattle) "Small Molecule Control of Signaling-Enzyme Function" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 pm | Ken Houk (University of California, Los Angeles) "Computational Design of New Enzymes" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Poster Talk #9: Brendan Orner (Nanyang Technological University) "Toward an Understanding of the Self-Assembly of Protein Cages and Application to Inorganic Nano-materials" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #10: Greg Tochtrop (Case Western Reserve University) "Metabolism and Signaling of Lipid Peroxidation Products" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #11: David Spiegel (Yale University) "Small Molecule Modulators of Antibody Function" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FRONTIERS IN BIOORGANIC AND MEDICINAL CHEMISTRY |
| Discussion Leader: Timothy Dore (University of Georgia) |
7:30 pm - 8:00 pm | Russell Petter (Avila Therapeutics) "Toward Digital Selectivity in Protease Inhibitors - Covalent Modification of a Non-catalytic Cysteine in HCV Protease" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Andrew Judd (Abbott Laboratories) "Industrial Applications of the RCM Reaction: From Twisted Amides to Productive Dimers" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Paul Wender (Stanford University) "The Chemistry-Medicine Continuum: New Approaches To Alzheimer's Disease, HIV/AIDS Eradication and Resistant Cancer" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |