SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Translational Bioorganic Chemistry |
| Discussion Leader: Laura Silvian (Biogen Idec) |
7:40 pm - 8:10 pm | Wayne Fairbrother (Genentech)
"Mechanism of IAP Antagonist-Induced Activation of cIAP Ubiquitin Ligase Activity" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Poster Talk #1: Violeta Marin (Abbott Laboratories)
"Deconvoluting the Cellular Targets of ABT-737 Using Parallel Chemical Proteomic Enrichment Strategies" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Tomi Sawyer (Aileron Therapeutics)
"Stapled Peptide Technology: Drug Design to Advance Novel Synthetic Biologics for Protein-Protein Interaction Targets" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Design & Engineering in Biological Systems |
| Discussion Leader: Eileen Kennedy (University of Georgia) |
9:00 am - 9:30 am | Nicola Pohl (Iowa State University)
"Synthetic Tools for Glycoimmunology" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Krishna Kumar (Tufts University)
"Modulation of Cellular Adhesion and Facilitated Delivery of Macromolecules Using Fluorinated Compounds" |
10:10 am - 10:20 am | Discussion |
10:20 am | Group Photo / Coffee Break |
10:50 am - 11:20 am | Takashi Morii (Kyoto University)
"A Modular Strategy for Tailoring Functional Ribonucleopeptides" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Ivan Correa (New England Biolabs)
"Studying Protein Dynamics in Living Cells Using the SNAP-tag Technology" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #2: Nicole Sampson (Stony Brook University)
"AROMPing Antibacterials" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Neuroscience & Neurological Disease |
| Discussion Leader: Hang (Hubert) Yin (University of Colorado) |
7:30 pm - 8:00 pm | Pam England (University of California, San Francisco)
"Molecular Probes for Neural Plasticity" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | William Bunnelle (Abbott Laboratories)
"Modulators of Neuronal Nicotinic Receptors as Novel Analgesics" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Doug Johnson (Pfizer)
"Chemical Biology with Clickable Probes: Application to the Discovery of FAAH Inhibitors and γ-Secretase Modulators" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Light Activated Probes & Biological Imaging |
| Discussion Leader: Shin Mizukami (Osaka University) |
9:00 am - 9:30 am | Joseph Kao (University of Maryland School of Medicine)
"Photochemical Neurobiology" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | David Lawrence (University of North Carolina)
"Organic Chemistry at the Edge of Biology: Taming Cell Behavior with Light Responsive Molecules" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Carsten Schultz (European Molecular Biology Laboratory, Heidelberg)
"Tools to Activate Intracellular Signaling Modules" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Poster Talk #3: Mark Distefano (University of Minnesota)
"Photochemical Modulation of Ras-Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #4: Thomas Magliery (Ohio State University)
"Combinatorial Approaches to Protein Design, Stability, and Interactions" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #5: Lei Wang (Salk Institute)
"Genetically Encoding Unnatural Amino Acids to Study Biological Processes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Bioenergy, Fuel Production, & Artificial Photosynthesis |
| Discussion Leader: Peter Yorgey (DSM Microbia) |
7:30 pm - 8:00 pm | Ronald Raines (University of Wisconsin)
"Chemical Approaches to Biofuels" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Charles Dismukes (Rutgers University)
"Hydrogen Metabolism in Realtime: Eliminating Bottlenecks to Biofuels" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Thomas Moore (Arizona State University)
"Imagine* Photosynthesis Where Human Ingenuity Supersedes Evolution" *John Lennon |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biological Mechanisms: Synthesis, Natural Products, & More |
| Discussion Leader: Jason Sello (Brown University) |
9:00 am - 9:30 am | Wendy Kelly (Georgia Institute of Technology)
"Harnessing the Thiostrepton Biosynthetic Machinery" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Jonathan Watts (University of Texas Southwestern Medical Center)
"Design and Synthesis of Nucleic Acid Analogues that Probe and Modulate Gene Expression" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Athanassios Giannis (Universität Leipzig)
"From Homer to Hedgehog: Chemistry, Biology, and Medical Perspectives of Cyclopamine" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Poster Talk #6: Danica Fujimori (University of California, San Francisco)
"RNA Methylation by Radical SAM Enzymes RlmN and Cfr" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #7: Wenjing Wang (Michigan State University)
"Reengineering of Cellular Retinol Binding Protein Type II (CRBPII) into a Rhodopsin Protein Mimic" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #8: Ratika Krishnamurty (University of Washington)
"Design, Synthesis, and Application of a Molecular Probe to Investigate the Conformational Dynamics of Src-Family Kinases" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Parasitic & Tropical Disease |
| Discussion Leader: Florian Seebeck (Max Planck Institute, Dortmund) |
7:30 pm - 8:00 pm | Paul Wyatt (University of Dundee)
"Neglected Diseases Drug Discovery in an Academic Setting" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Craig Thomas (National Human Genome Research Institute)
"Opportunities in Rare and Neglected Diseases: Reductases as Targets for Therapeutic Intervention within Schistosomiasis and Hookworm" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jeremy Burrows (Medicines for Malaria Venture)
"The Journey to New Clinical Antimalarials" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Screening & Discovery |
| Discussion Leader: Swati Prasad (AstraZeneca R&D Boston) |
9:00 am - 9:30 am | Sarah Luchanski and Rishi Jain (Novartis Institutes for Biomedical Research)
"Chemo-Centric Approaches to Target Discovery in the Hedgehog Signaling Pathway" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Randall Peterson (Harvard Medical School)
"Discovering Novel Behavior-Modifying Compounds" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Jerry Pelletier (McGill University)
"RNA Helicases as Drug Targets" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Poster Talk #9: Webster Santos (Virginia Tech)
"Branched Peptide Libraries to Disrupt Protein-RNA Interactions" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #10: Danielle Dube (Bowdoin College)
"A Chemical Approach to Discover and Target Helicobacter pylori's Glycoproteins" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #11: George Zheng (Georgia State University)
"Chemical Probes of Protein Arginine Methylation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Frontiers of Bioorganic Chemistry |
| Discussion Leader: Joshua Finkelstein (Nature Publishing Group) |
7:30 pm - 8:00 pm | Ernest Giralt (Institute for Research in Biomedicine, Barcelona)
"Molecular Recognition at Protein Surfaces" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Mark Murcko (Vertex Pharmaceuticals)
"Learning from Cellular Data" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Laura Kiessling (University of Wisconsin)
"Synthetic Surfaces to Control Cell Fate" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |