| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Modern Approaches to Antibacterials |
| Discussion Leader: Paramjit Arora (NYU) |
| 7:40 pm - 8:10 pm | Clif Barry (NIH/NIAID)
"The Unique Challenges of Drug Discovery for Tuberculosis" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:35 pm | Poster Talk: Rahul Kohli (UPenn)
"Combating Antibiotic Resistant Bacteria by Targeting the SOS Pathway" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:15 pm | Deb Hung (Harvard Medical School / Massachusetts General Hospital / Broad Institute of MIT & Harvard)
"Small Molecule Approach to Understanding Infection" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Diversity of Natural Products |
| Discussion Leader: Bill Wuest (Temple) |
| 9:00 am - 9:30 am | Brad Moore (UC San Diego/Scripps Oceanography)
"Rewriting Natural Product Drug Discovery Through Synthetic Biology" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Carole Bewley (NIDDK/NIH)
"Anti-Infectives from Nature" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | David Sherman (University of Michigan)
"The Lego-Ization of Polyketide Biosynthesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Shiou-Chuan (Sheryl) Tsai (UC Irvine)
"Catching Mega-Synthase In Action: The Synthetic Biology of Polyketides and Fatty Acids" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk: Jason Sello (Brown)
"Reimagining Natural Products with Anti-Cancer Activity as Anti-Infectives" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Carbohydrates in Life and Medicine |
| Discussion Leader: Amanda Hargrove (Duke) |
| 7:30 pm - 8:00 pm | Jennifer Kohler (UT Southwestern)
"Photocrosslinking Sugars Enable Discovery of Novel Toxin Receptors" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Linda Hsieh-Wilson (Cal Tech)
"Carbohydrate Signaling in Neurobiology and Disease" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Ben Davis (Oxford)
"Sugars and Proteins" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | New Directions in Chemical Biology |
| Discussion Leader: Krishna Kumar (Tufts) |
| 9:00 am - 9:30 am | Jamie Williamson (Scripps Research Institute)
"Cofactors and Chaperones in Ribosome Assembly" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | John Cronan (UIUC)
"A Strange Work-Around in Synthesis of Quorum Signaling Cis-2 Fatty Acids" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | David Liu (Harvard)
"Integrating Chemistry and Evolution to Illuminate and Program Biology" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Poster Talk: Lindsay Comstock (Wake Forest)
"Probing Biological Methylation with N-Mustard Analogs of S-Adenosyl-L-Methionine" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Poster Talk: Joshua Kritzer (Tufts)
"Conformational Control of Peptide Function and Cell Penetration" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk: Kyle Dunbar (UIUC)
"Elucidating the Mechanism of Azoline Formation in Ribosomal Natural Product Biosynthesis" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Challenges of Non-Traditional Drug Discovery |
| Discussion Leader: Jim Kiefer (Genentech) |
| 7:30 pm - 8:00 pm | Eric Rubin (Harvard School of Public Health)
"Antibiotic Therapy: Why Doesn't One Dose in One Day Keep the Doctor Away?" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Eli Wallace (Peloton)
"Selective Kinase Inhibition for the Treatment of Cancer" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Natalie Strynadka (U. British Columbia)
"Structure-Based Analysis and Inhibition of Beta-Lactam Antibiotic Resistance Mechanisms" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Innovation in Drug Discovery |
| Discussion Leader: Eli Wallace (Peloton) |
| 9:00 am - 9:30 am | Peter Senter (Seattle Genetics)
"Empowered Antibodies for Cancer Therapy" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Siegfried Reich (eFFECTOR Therapeutics)
"Targeting Protein Translational Control with Disciplined Chemistry" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Andreas Gosberg (Lilly)
"Efficiency Based Prosecution of Fragment Based Lead Generation" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Poster Talk: James Chambers (UMass Amherst)
"Modular Probes for Imaging Neuronal Receptors" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Poster Talk: Jianfeng Cai (South Florida)
"AApeptide: From Structure to Function" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk: Xiangshu Xiao (Oregon Health and Science)
"Chemical Genetic Discovery of Lamin-Binding Ligands" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Approaches to Molecular Technologies |
| Discussion Leader: Y. George Zheng (U. Georgia) |
| 7:30 pm - 8:00 pm | Stefan Lohmer (Axxam SpA)
"A 'Bright' Future: When Optogenetics Meet with Voltage-Gated Ion Channels" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | David Perrin (U. British Columbia)
"Kit-Like Aqueous One-Step 18F-Labeling of Peptides for Functional PET Imaging" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Scott Phillips (Penn State)
"Interfacing Organic and Analytical Chemistry to Advance Point-of-Care Diagnostics" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | New Targets for Therapeutic Development |
| Discussion Leader: Jay Schneekloth (NIH/NCI) |
| 9:00 am - 9:30 am | Dewey McCafferty (Duke)
"Chemical Biology of Bacterial Pathogenesis" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Byron DeLaBarre (Agios)
"Exploiting Allostery in Drug Discovery for Metabolic Targets" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Emily Balskus (Harvard)
"Gut Reactions: Exploring the Chemistry of the Human Microbiota"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Seok-Yong Lee (Duke)
"Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk: John Tomsho (University of the Sciences)
"Disruption of NS1A Dimerization as a Potential Target for Influenza Therapies" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Modern Approaches to Global Health |
| Discussion Leader: Jerome Zeldis (Celgene Global Health) |
| 7:30 pm - 8:00 pm | Carl Nathan (Weill Cornell)
"Inhibitors of Non-Replicating Mycobacterium tuberculosis" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Jeremy Burrows (Medicines for Malaria Venture)
"Molecules to Eradicate Malaria" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | David Matthews (University of Toronto)
"Structure-Guided Design of an Antimalarial Clinical Candidate Targeting Drug Resistant Dihydrofolate Reductase" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
