Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Beyond the Base-Pair: Recognition of Nucleic Acids |
| Discussion Leader: Bruce Armitage (Carnegie Mellon University, USA) |
7:40 pm - 8:10 pm | Jacqueline Barton (California Institute of Technology, USA) "DNA Signaling" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Deborah Wuttke (University of Colorado, USA) "Tying up the Ends: Managing ssDNA at Telomeres" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Danith Ly (Carnegie Mellon University, USA) "Bifacial Recognition of Nucleic Acids" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Design of New Cellular Tools for Biology |
| Discussion Leader: Brian Callahan (Binghamton University, SUNY, USA) |
9:00 am - 9:30 am | Stephen Miller (University of Massachusetts Medical School, USA) "Beyond D-Luciferin: A Bright Future for Bioluminescence" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Jennifer Prescher (University of California, Irvine, USA) "Expanding the Imaging Toolbox" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Keith Wood (Promega, USA) "Deciphering Phenotypic Drug Screening Targets Using a Chloroalkane Capture Tag" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | David Chenoweth (University of Pennsylvania, USA) "Chemical Approaches for Spatial and Termporally Defined Probing of Biological Systems" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Qing Lin (University at Buffalo, State University of New York, USA) "Development of Tetrazole-Based Photoclick Chemistry for Biological Applications" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Jason Belitsky (Oberlin College, USA) "Catechol-Based Coatings Inspired by Melanin as Colorimetric Metal-Ion Sensors" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Improving on Nature |
| Discussion Leader: Kimberly Beatty (Oregon Health and Science University, USA) |
7:30 pm - 8:00 pm | Floyd Romesberg (The Scripps Research Institute, USA) "A Semi-Synthetic Organism with an Expanded Genetic Alphabet" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | William Wuest (Temple University, USA) "Draining the Moat: Natural Product-Inspired Approaches to Combat Bacterial Biofilms" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Patrick Brown (Impossible Foods Inc., USA) "Replacing the World's Most Destructive Industry" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Chemical
Biology of Post-Translational Modification |
| Discussion Leader: Lindsey James (University of North Carolina, USA) |
9:00 am - 9:30 am | Danica Fujimori (University of California, San Francisco, USA) "Allosteric Regulation in Histone Demethylases" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Ingrid Wertz (Genentech, USA) "Development of a Multiplexed Proteomic Platform to Quantitate Deubiquitinase Activity Across Biological Samples" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Dorothee Kern (Howard Hughes Medical Institute / Brandeis University, USA) "The Evolution of Kinase Dynamics Over 1 Billion Years Reveals a Modern Cancer Drug’s Mechanism" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Jordan Meier (National Cancer Institute, NIH, USA) "New Insights into Protein Acetylation from Chemoproteomics" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Brent Martin (University of Michigan, USA) "Multiscale Chemical Approaches to Map Oxidative Stress" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Alon Gorodetsky (University of California, Irvine, USA) "Cephalopod-Derived Materials for Photonic and Protonic Devices" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Proteins and Peptides with Novel Functions |
| Discussion Leader: Joshua Kritzer (Tufts University, USA) |
7:30 pm - 8:00 pm | Samuel Gellman (University of Wisconsin - Madison, USA) "Mimicry of Information-Rich Protein Surfaces with Alpha/Beta-Peptide Foldamers" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Paramjit Arora (New York University, USA) "Towards a Systematic Approach for Targeting Protein-Protein Interactions" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Tariq Ghayur (Abbvie, USA) "Opportunities and Challenges of Developing the Next-Generation of Bi- and Multi- Specific Antibody Drugs" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Strategies for Drug Discovery's Most Difficult Targets |
| Discussion Leader: Samy Meroueh (Indiana University, USA) |
9:00 am - 9:30 am | Eric Olson (Syros Pharmaceuticals, USA) "Discovery and Development of Drugs Targeting CFTR for the Treatment of Cystic Fibrosis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Nick Terrett (Ensemble Therapeutics, USA) "Exploring Macrocycles for Protein-Protein Interaction Targets: The Discovery of Novel Bifunctional XIAP Antagonists" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Lee Rubin (Harvard University, USA) "A Chemical Biology Approach to Understanding and Treating Motor Neuron Diseases" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Giorgio Colombo (National Research Council of Italy, Italy) "Modifying Hsp90 Dynamics and Functional Relationships Through Rationally Designed Allosteric Activators" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Meredith Hartley (Oregon Health and Science University, USA) "Investigating Thyroid Hormone Mimetics as a Therapeutic Strategy for Neurological Myelin Disorders" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Juan Pablo Maianti (Harvard University, USA) "Substrate-Selective Inhibitors of Insulin-Degrading Enzyme" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Harnessing the Immune System for Cancer |
| Discussion Leader: John Harlan (AbbVie, USA) |
7:30 pm - 8:00 pm | John Lambert (ImmunoGen, Inc., USA) "ADCs: After Kadcyla, What's Next" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | David Rabuka (Redwood Bioscience, USA) "Generating ADCs Using Chemoenzymatic Site-Specific Protein Conjugation" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Toni Kline (Sutro Biopharma, USA) "Synthetic Biology and Synthetic Chemistry Converge for Novel Antibody-Drug Conjugates" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Forward and Reverse Chemical Genetics |
| Discussion Leader: Milka Kostic (Cell Press - Chemistry & Biology, USA) |
9:00 am - 9:30 am | Matthew Bogyo (Stanford University School of Medicine, USA) "Using Small Molecules to Identify Novel Regulators of Inflammatory Cell Death" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Craig Thomas (National Institutes of Health, USA) "Linking Mechanism to Phenotype: Surprises in the Data" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Bryan Roth (University of North Carolina, USA) "New Technologies for GPCR-ology" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Charles Melancon (University of New Mexico, USA) "Detecting Ribosome Inhibitors in Living Bacteria Using an Orthogonal Ribosome-Based Fluorescent Sensor" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Martin Pettersson (Pfizer Neuroscience Medicinal Chemistry, USA) "Phenotypic Screening: Identification of Pan Class I HDAC Inhibition as a Novel Mechanism for Regulating Astrocytic ApoE Secretion" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Tanya Schneider (Connecticut College, USA) "A Dual Role for Bacterial Regulator Proteins: Quorum Sensing and Oxidative Stress Response" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structural Evaluation of Protein-Molecule Interactions |
| Discussion Leader: Jason Gestwicki (University of California, San Francisco, USA) |
7:30 pm - 8:00 pm | Derek Lowe (Vertex Pharmaceuticals Inc., USA) "New Platforms For Lead Generation via Bioorganic Chemistry" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Jolanta Grembecka (University of Michigan, USA) "Structure-Based Development of Potent Small Molecule Inhibitors of Protein-Protein Interactions: Application to Menin-MLL Inhibitors" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Gregory Weiss (University of California, Irvine, USA) "Listening to Enzymes Revving with Carbon Nanocircuits" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |