Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Diversity of Chemistry in Nature |
| Discussion Leader: Michael Burkart (University of California, San Diego, USA) |
7:40 pm - 8:05 pm | Michael Fischbach (University of California, San Francisco, USA) "Small Molecules from the Human Microbiota" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Amy Wright (Florida Atlantic University, USA) "Exploring Marine Biodiversity for Potential Therapeutics" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Craig Townsend (Johns Hopkins University, USA) "Carbapenems: Biosynthesis, Pathway Engineering and Lessons from Tuberculosis" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Applications of Bioorthogonal Chemistry |
| Discussion Leader: Kabirul Islam (University of Pittsburgh, USA) |
9:00 am - 9:30 am | Joseph Fox (University of Delaware, USA) "Interfacial Bioorthogonal Chemistry: Discovery, Development, and Applications" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Kate Carroll (The Scripps Research Institute, USA) "Cysteine-Mediated Redox Signaling: Chemical Tools for Biological Discovery and Beyond" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Thomas Sakmar (The Rockefeller University, USA) "Bioorthogonal Labeling of Engineered Membrane Proteins to Enable Single Molecule Imaging" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Selected from Poster Abstracts: Jennifer Heemstra (University of Utah, USA) "Nucleic Acids for Biosensing, Bioimaging, and Drug Delivery" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: Zhen Huang (Pfizer Worldwide Research and Development, USA) "Profiling Adduct Stability of Covalent Serine Hydrolase Inhibitors in Cells" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Yimon Aye (Cornell University / Weill Cornell Medicine, USA) "Targeting Gain-of-Function Redox Events that Safeguard Metazoan Health and Survival" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Milka Kostic (Cell Chemical Biology, Cell Press, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Illuminating Biology with Imaging |
| Discussion Leader: Timothy Dore (New York University Abu Dhabi, United Arab Emirates) |
7:30 pm - 8:00 pm | Alice Ting (Massachusetts Institute of Technology, USA) "Spatially-Resolved Proteomic Mapping of Living Cells" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Luke Lavis (Janelia Research Campus, Howard Hughes Medical Institute, USA) "Building Brighter Fluorophores for Cellular Imaging" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Marcel Bruchez (Carnegie Mellon University, USA) "The Fluorogen Switch: Rational Design of Fluorogenic Sensors and Optogenetic Tools" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Bio-Inspired Synthesis |
| Discussion Leader: Daniel Appella (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) |
9:00 am - 9:30 am | Jennifer Cochran (Stanford University, USA) "Engineered Peptide-Drug Conjugates for Tumor Targeting Applications" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Eric Schmidt (University of Utah, USA) "The Posttranslational Modification Toolkit for Total Synthesis" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Helma Wennemers (ETH Zurich, Switzerland) "Bioinspired Chemistry with Proline-Rich Peptides" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Michael Jewett (Northwestern University, USA) "Repurposing Ribosomes for Synthetic Biology" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Kristen DeMeester (University of Delaware, USA) "Bioorthogonal Labeling
on the Carbohydrate Backbone of E. coli Peptidoglycan" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Sarah Wallrodt (University of Konstanz, Germany) "NAD+ Analogs for Cellular Imaging of Poly(ADP-ribos)ylation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Glycans in Health and Biology |
| Discussion Leader: Lara Mahal (New York University, USA) |
7:30 pm - 8:00 pm | David Vocadlo (Simon Fraser University, Canada) "New Chemical Biology Tools for Studying Glycoconjugates In Vivo" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Pauline Rudd (National Institute for Bioprocessing Research and Training (NIBRT), Ireland) "Glycoscience and the Systems Biology of Disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | James Paulson (The Scripps Research Institute, USA) "Modulating Immune Responses with Siglec Targeted Nanoparticles" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemoproteomics in Therapeutic Applications |
| Discussion Leader: Brent Martin (University of Michigan, USA) |
9:00 am - 9:30 am | Daniel Nomura (University of California, Berkeley, USA) "Mapping Metabolic Drivers of Disease Using Chemoproteomic and Metabolomic Platforms" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Markus Schirle (Novartis Institutes for Biomedical Research, USA) "Chemoproteomics-Based Approaches for Target Deconvolution of Bioactive Compounds" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Stephan Sieber (Technical University of Munich, Germany) "Chemical Tools to Manipulate Bacterial Pathogenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Selected from Poster Abstracts: Michael Cohen (Oregon Health and Science University, USA) "A Chemical Genetics Approach for Identifying Family-Member Specific Targets of ARTDs" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: Keriann Backus (The Scripps Research Institute, USA) "Proteome-Wide Covalent Ligand Discovery in Native Biological Systems" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Amit Choudhary (Broad Institute of MIT and Harvard / Harvard Medical School, USA) "Multidimensional Chemogenic Control of CRISPR-Cas9 in Cells and Organisms" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Drug Discovery and Therapeutics |
| Discussion Leader: David Rabuka (Catalent Pharma Solutions, USA) |
7:30 pm - 8:00 pm | Adam Johnson (Genentech, USA) "Battling BTK Mutants" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Markus Bantscheff (Cellzome GmbH, Germany) "Comprehensive Drug Target Profiling Using Orthogonal Chemoproteomics Technologies" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Gray (Pfizer, Inc, USA) "Probing Molecular Features Which Contribute to Agonism and Signaling Bias at the Dopamine D1 Receptor" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Approaches to Tame Intractable Targets |
| Discussion Leader: Amanda Hargrove (Duke University, USA) |
9:00 am - 9:30 am | Yueming Li (Memorial Sloan Kettering Cancer Center, USA) "Regulation of Gamma-Secretase: From Small Molecules to Modulatory Subunits" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Robert Garbaccio (Merck and Co., Inc., USA) "An Antibody-Drug Conjugate Approach to Tissue-Selective Glucocorticoids" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | M.G. Finn (Georgia Institute of Technology, USA) "Virus-Like Particle Based Delivery of Biological Function" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Selected from Poster Abstracts: Ryan Mehl (Oregon State University, USA) "Ideal Bioorthogonal Ligations with Genetic Code Expansion" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: John Schneekloth (National Cancer Institute, NIH, USA) "Targeting Structurally and Functionally Diverse RNAs with Druglike Small Molecules" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Henning Stockmann (AbbVie Inc., USA) "Glycan-Mediated Click Chemistry for Drug-Target Identification" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advances in Chemical Biology |
| Discussion Leader: John Koh (University of Delaware, USA) |
7:30 pm - 8:00 pm | Paola Castaldi (AstraZeneca, USA) "Small Molecules Driven Chemical Biology and Target Deconvolution Strategies" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | John Pezacki (University of Ottawa, Canada) "Being SMART and Staying Active: Uncovering the Roles of RNAs and Enzymes in Host-Virus Interactions" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Gabriela Chiosis (Memorial Sloan Kettering Cancer Center, USA) "Chemical Biology Approach to the Chaperome - From Mechanisms to Drugs and Diagnostics" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |