Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Intra and Extracellular Biomolecular Recognition
Discussion Leader: Richard Cheng (National Taiwan University, Taiwan)
7:40 pm - 8:05 pm
James Wells (University of California, San Francisco, USA)
"Discovering and Modulating How Cell Surfaceomes Change in Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Tarun Kapoor (The Rockefeller University, USA)
"Chemical Approaches to Dissect the Diverse Functions of Proteins in the AAA+ Superfamily"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Laura Kiessling (University of Wisconsin-Madison, USA)
"Glycans as Cell IDs"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Disorder and Dynamics
Discussion Leader: Michelle Farkas (University of Massachusetts Amherst, USA)
9:00 am - 9:30 am
Jane Clarke (University of Cambridge, United Kingdom)
"Analyses of Folding and Binding of Intrinsically Disordered Proteins"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Anna Mapp (University of Michigan, USA)
"From Fuzzy to Function: The New Frontier of Protein-Protein Interactions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Kevin Gardner (CUNY Advanced Science Research Center, USA)
"Ligand-Controlled Conformational Plasticity: Lessons Learned from Natural and Artificial Control of Protein-Protein Interactions"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
Dustin Maly (University of Washington, USA)
"Engineered Protein Switches for Studying Intracellular Signaling Dynamics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Rosaura Padilla-Salinas (BioFrontiers Institute, University of Colorado Boulder, USA)
"Development of Novel Chemical Biology Tools to Combat Autoimmunity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Joshua Yim (Stanford University School of Medicine, USA)
"Developing Optical Chemical Probes for Imaging Proteolytic Signatures"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Anna Mapp (University of Michigan, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Chemical Biology
Discussion Leader: Derek Tan (Memorial Sloan Kettering Cancer Center, USA)
7:30 pm - 8:00 pm
Jerry Adams (GlaxoSmithKline, USA)
"Harnessing the Immune System to Fight Cancer: What Will Be the Role of Small Molecule Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Jeanne Magram (Northern Biologics, Canada)
"Targeting the Tumor Microenvironment with Antibody Therapeutics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Peter Schultz (The Scripps Research Institute, USA)
"A Chemist's Foray into Translational Research - From Stem Cells to Neglected Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Challenges in Nucleic Acids Recognition and Therapeutics
Discussion Leader: Emily Derbyshire (Duke University, USA)
9:00 am - 9:30 am
Yamuna Krishnan (University of Chicago, USA)
"Fluorescent DNA Nanodevices to Quantitate Protein Activity in Living Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Aseem Ansari (University of Wisconsin-Madison, USA)
"Cosmic-Seq Based Surprises on How Synthetic Genome Readers Engage Chromatinized Genomes in Live Human Stem Cells"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Joshua Brooks (Ionis Pharmaceuticals, USA)
"Process Development in Antisense Oligonucleotides"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Pierre Stallforth (Hans Knoell Institute, Germany)
"Social Amoebae: A Rich Source of Natural Products"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Pamela Peralta-Yahya (Georgia Institute of Technology, USA)
"Olfactory Receptor-Based Sensors to Accelerate the Engineering of Chemical-Producing Microbes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Bo Li (University of North Carolina at Chapel Hill, USA)
"Dithiolopyrrolones as Antibiotics and Organocatalysts for Protein Oxidation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Target and Organism-Based Drug Discovery
Discussion Leader: Paola Castaldi (AstraZeneca, USA)
7:30 pm - 8:00 pm
Matthew Schiffler (Eli Lilly and Company, USA)
"mPGES-1 Inhibitors from Start to Finish"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Stacie S. Canan (Celgene Global Health, USA)
"In Vitro Whole Organism SAR Coupled with Rapid Advancement to In Vivo Proof-of-Concept Studies to Drive Anti-Malarial Drug Discovery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Gilles Bignan (Janssen Research & Development, USA)
"Discovery and Development of Potent and Efficacious Pan-Mutant Androgen Receptor Antagonists"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Margot Paulick (Union College, USA)
"Synthesis and Evaluation of Cell-Permeable Analogs of Trehalose to Improve the Viability of Preserved Mammalian Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Understanding and Exploiting the Immune System
Discussion Leader: Marina Rubini (University College Dublin, Ireland)
9:00 am - 9:30 am
Catherine Leimkuhler Grimes (University of Delaware, USA)
"Breaking Down and Remodeling Bacterial Cell Walls"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Steve Kolodziej (Pfizer, USA)
"Oligosaccharide Models to Study Regioselectivity of Chemical Activation and Protein Conjugation for Conjugate Vaccines"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Carston Wagner (University of Minnesota, USA)
"Chemically Self-Assembled Nanorings: From CARS to PARS"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Martin Schnermann (National Cancer Institute, NIH, USA)
"Near-IR Uncaging Chemistry: Discovery and Applications"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Kimberly Beatty (Oregon Health and Science University, USA)
"A New Technology for Tracking Cellular Proteins at High Resolution"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Kamil Godula (University of California, San Diego, USA)
"Chemical Editing of the Cellular Glycocalyx to Influece Cellular Functions"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Protein Recognition and Function
Discussion Leader: Louise Charkoudian (Haverford College, USA)
7:30 pm - 8:00 pm
Marcey Waters (University of North Carolina at Chapel Hill, USA)
"Strategies for Sensing Histone Post-Translational Modifications"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Jason Gestwicki (University of California, San Francisco, USA)
"Targeting Protein-Protein Interactions in the Molecular Chaperone Network"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: David Chenoweth (University of Pennsylvania, USA)
"Rational Redesign of the Collagen Triple Helix Interface"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Neal Zondlo (University of Delaware, USA)
"C-H/π and S-H/π Interactions in Biomolecular Structure, Assembly, and Engineering"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Labeling, Folding and Degrading Proteins
Discussion Leader: Brian McNaughton (Colorado State University, USA)
9:00 am - 9:30 am
Andy Crew (Arvinas, Inc., USA)
"Proteolysis-Targeting Chimera (PROTACs) as Potent and Selective Degraders of Pathological Proteins"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
George Rose (Johns Hopkins University, USA)
"Protein Folding: Non-Specific Interactions Can Promote Highly Specific Chain Organization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Ronald Raines (University of Wisconsin-Madison, USA)
"Diazo Compounds: Versatile Tools for Chemical Biology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: John Jewett (University of Arizona, USA)
"Triazabutadienes as Probes for the Biochemical Environment"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Abhishek Chatterjee (Boston College, USA)
"Modelling Protein Post-Translational Modification in Eukaryotes Using Universal Genetic Code Expansion Systems"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Ratmir Derda (University of Alberta, Canada)
"Discovery of Functional Ligands from Genetically-Encoded Chemically-Modified Peptide Libraries"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Recent Advances in Chemical Biology
Discussion Leader: Jennifer Ottesen (Ohio State University, USA)
7:30 pm - 8:00 pm
Hiroaki Suga (University of Tokyo, Japan)
"One-Pot Synthesis and Screening of Pseudo-Natural Peptides and Products"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
David Breslauer (Bolt Threads, USA)
"Using Industrial Biotechnology to Make Spider Silk and Other Protein-Based Fibers"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Alanna Schepartz (Yale University, USA)
"Seeing and Engineering Inside Cells"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
