Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Intra and Extracellular Biomolecular Recognition
7:40 pm - 8:05 pm
"Discovering and Modulating How Cell Surfaceomes Change in Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Chemical Approaches to Dissect the Diverse Functions of Proteins in the AAA+ Superfamily"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Disorder and Dynamics
9:00 am - 9:30 am
"Analyses of Folding and Binding of Intrinsically Disordered Proteins"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"From Fuzzy to Function: The New Frontier of Protein-Protein Interactions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Ligand-Controlled Conformational Plasticity: Lessons Learned from Natural and Artificial Control of Protein-Protein Interactions"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Engineered Protein Switches for Studying Intracellular Signaling Dynamics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Development of Novel Chemical Biology Tools to Combat Autoimmunity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Developing Optical Chemical Probes for Imaging Proteolytic Signatures"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Chemical Biology
7:30 pm - 8:00 pm
"Harnessing the Immune System to Fight Cancer: What Will Be the Role of Small Molecule Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Targeting the Tumor Microenvironment with Antibody Therapeutics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Chemist's Foray into Translational Research - From Stem Cells to Neglected Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Challenges in Nucleic Acids Recognition and Therapeutics
9:00 am - 9:30 am
"Fluorescent DNA Nanodevices to Quantitate Protein Activity in Living Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Cosmic-Seq Based Surprises on How Synthetic Genome Readers Engage Chromatinized Genomes in Live Human Stem Cells"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Process Development in Antisense Oligonucleotides"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Social Amoebae: A Rich Source of Natural Products"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Olfactory Receptor-Based Sensors to Accelerate the Engineering of Chemical-Producing Microbes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Dithiolopyrrolones as Antibiotics and Organocatalysts for Protein Oxidation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Target and Organism-Based Drug Discovery
7:30 pm - 8:00 pm
"mPGES-1 Inhibitors from Start to Finish"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"In Vitro Whole Organism SAR Coupled with Rapid Advancement to In Vivo Proof-of-Concept Studies to Drive Anti-Malarial Drug Discovery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Discovery and Development of Potent and Efficacious Pan-Mutant Androgen Receptor Antagonists"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Synthesis and Evaluation of Cell-Permeable Analogs of Trehalose to Improve the Viability of Preserved Mammalian Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Understanding and Exploiting the Immune System
9:00 am - 9:30 am
"Breaking Down and Remodeling Bacterial Cell Walls"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Oligosaccharide Models to Study Regioselectivity of Chemical Activation and Protein Conjugation for Conjugate Vaccines"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Chemically Self-Assembled Nanorings: From CARS to PARS"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Near-IR Uncaging Chemistry: Discovery and Applications"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A New Technology for Tracking Cellular Proteins at High Resolution"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Chemical Editing of the Cellular Glycocalyx to Influece Cellular Functions"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Protein Recognition and Function
7:30 pm - 8:00 pm
"Strategies for Sensing Histone Post-Translational Modifications"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Targeting Protein-Protein Interactions in the Molecular Chaperone Network"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Rational Redesign of the Collagen Triple Helix Interface"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"C-H/π and S-H/π Interactions in Biomolecular Structure, Assembly, and Engineering"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Labeling, Folding and Degrading Proteins
9:00 am - 9:30 am
"Proteolysis-Targeting Chimera (PROTACs) as Potent and Selective Degraders of Pathological Proteins"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Protein Folding: Non-Specific Interactions Can Promote Highly Specific Chain Organization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Diazo Compounds: Versatile Tools for Chemical Biology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Triazabutadienes as Probes for the Biochemical Environment"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Modelling Protein Post-Translational Modification in Eukaryotes Using Universal Genetic Code Expansion Systems"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Discovery of Functional Ligands from Genetically-Encoded Chemically-Modified Peptide Libraries"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Recent Advances in Chemical Biology
7:30 pm - 8:00 pm
"One-Pot Synthesis and Screening of Pseudo-Natural Peptides and Products"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Using Industrial Biotechnology to Make Spider Silk and Other Protein-Based Fibers"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Seeing and Engineering Inside Cells"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure