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Bioorganic Chemistry

Gordon Research Conference

The Development of Chemical Probes to Decipher Biology

June 10 - 15, 2018

Chairs

and

Vice Chairs

and

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Conference Description

The Bioorganic Chemistry Gordon Research Conference (GRC) was established in 1992 to bring together scientists pursuing challenges at the interface of chemistry and biology. Attendees from industry and academia meet annually to discuss the latest chemical tools that have been developed to modulate and interrogate biological complexity. The 2018 meeting will focus on liganding undruggable targets, targeting RNA with small molecules, chemical microbiology, the development of new chemical tools to unlock biology and translating small molecule probes into therapeutics. Conferees are encouraged to present posters. Poster presenters should submit an abstract with their applications on the GRC web site. A number of poster presenters will be invited to present short talks. As this meeting usually oversubscribes, submission of applications in early 2018 is strongly encouraged.

Related Meeting

This GRC will be held in conjunction with the "Bioorganic Chemistry" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Covalent Inhibitors as Drugs Discussion Leader:
7:40 pm - 8:05 pm	"New Pharmacological Approaches to Kinase Inhibitor Discovery: Degradation, Allostery and Covalence"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Applying Chemical Biology Probes for the EGFRT790M Covalent Inhibitor Program"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Chemical Approaches to Probe Signaling by Dynamic Proteome Lipidation"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Selective Inhibition of Translation with Small Molecules"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Inhibition of Monoacylglycerol Lipase for the Treatment of Neurological Disorders"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Chromatin Modifying Enzymes Discussion Leader:
9:00 am - 9:30 am	"Targeting Epigenomic Complexes"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Targeting Reversible Lys Modifications with Designed Small Molecules"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Regulation and Small Molecule Inhibition of Chromatin Demethylation"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"An Expanded Landscape of Acetylation in Signaling from Chemoproteomics"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Fluorinated Proteins as Enabling Tools for Small Molecule Discovery in Epigenetics"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Protein and Small Molecule Engineering Towards a Programmable Chromatin Landscape"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Liganding Undruggable Targets Discussion Leader:
7:30 pm - 8:00 pm	"Site-Directed Screening: Harnessing Cysteines to Modulate Challenging Targets"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Expanding the Druggable Proteome Through Cereblon-Mediated Protein Degradation"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"PROTACs and Induced Protein Degradation: The 17-Year Old Overnight Phenomenon"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Chemical Microbiology Discussion Leader:
9:00 am - 9:30 am	"Using Genome-Wide Mutant Fitness Profiles to Decipher Compound Mechanism"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Leader Peptide Guided Natural Product Biosynthesis"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Harnessing the Chemistry of Alkaloid-Producing Plants"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Capturing Transient Interactions of Proteins Involved in Natural Product Biosynthesis"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Regulated Expression of the (Non-)Annotated Proteome"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Non-Traditional Role of Lipids in Programmed Cell Death"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Chemical Biology in Drug Discovery Discussion Leader:
7:30 pm - 8:00 pm	"New Approaches to the Discovery and Delivery of Agents Targeting RNA-Mediated Disease"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Chemistry Meets Omics: Understanding How Drugs Work"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Chemical Biology Approach for Small Molecule Inhibitor Mechanism of Action Studies in Living Cells"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"PhABits Shine Lght on Fragment-Protein Binding"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Imaging and Optochemical Control Discussion Leader:
9:00 am - 9:30 am	"Illuminating the Biochemical Activity Architecture of the Cell"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Optical Control of GPCRs and Kinases"
10:10 am - 10:20 am	Discussion
10:20 am - 10:40 am	Coffee Break
10:40 am - 11:10 am	"Optical Control of Protein Function in Cells and Animals"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Harnessing Nucleic Acid Molecular Recognition for Fluorescence-Based Biomolecular Imaging"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Biocatalysis: Harnessing the Power of Nature's Tools to Build Complex Molecules"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Development of Short Peptoids as Antifungal Agents Against C. neoformans"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Small Molecule Cleavage of a Toxic RNA Repeat"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Modulating Protein Function Discussion Leader:
7:30 pm - 8:00 pm	"Sugars and Proteins"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Pseudo Natural Products for Phenotypic Small Molecule Discovery"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Discovery and Engineering Plant Chemistry"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Targeting RNA with Small Molecules Discussion Leader:
9:00 am - 9:30 am	"Sequence-Based Design of Small Molecules Targeting RNA"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Discovering the Pervasive Roles for Structure in ncRNA and mRNA Function"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"RNA-Targeted Small Molecules: A Problem in Drug Discovery"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Deciphering Patterns in Selective Small Molecule: RNA Interactions"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Targeting Structurally and Functionally Diverse RNAs with Druglike Small Molecules"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Selective Small Molecule Inhibition of an RNA Structural Element"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	New Chemical Tools to Unlock Biology Discussion Leader:
7:30 pm - 8:00 pm	"A Twist in the Tail? Precision Electrophile Sensing Guides Isoform-Selective Covalent Ligand Evolution"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Riboswitching on the Light: Illuminating the Single-Cell Biology of Bacterial Signals"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Inositol Pyrophosphate Signaling Revealed with Chemical Tools"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Dana-Farber Cancer Institute - Chemical Biology Program

Conference Links

Conference History Bioorganic Chemistry (GRS)

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