Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Translational Chemical Biology
7:40 pm - 8:10 pm
"Glycans at the Host-Microbe Interface"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Targeting DOT1L Recruitment in MLL-Rearranged Leukemia"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Illuminating Protein Homeostasis and Preventing Pathogenesis with Bioactive Small Molecules"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Using Chemical Biology to Interrogate the Connection Between Altered Circadian Rhythms and Cancer"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Probes for Imaging
9:00 am - 9:30 am
"Probes for Dissecting In Vivo Pharmacology Using Confocal Microscopy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Light-Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Electrophysiology, Unplugged: Fluorescent Tools to Watch Cells in Action"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Strategy for Cell Selective Imaging Probe Development"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Multiplexed In Vivo Imaging with Shortwave Infrared Fluorophores"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Accelerating Drug Discovery Through the Power of Microscopy Images"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Automation, Big Data and Machine Learning in Drug Discovery
7:30 pm - 8:00 pm
"AI-Assisted Drug Discovery: What, How and Why?"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Chemical Probes for Cancer Medicine: The Data and the Data Science"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Superficial Intelligence: Putting Machine Learning to Work in Drug Discovery"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Probes and Leads: Discovery and Triage
9:00 am - 9:30 am
"SLC Transporter Chemical Biology"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Public Data for Chemical Biology: The Past, the Current and the Future"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Chemical Tools for Unraveling Parasite Biology"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Small-Molecule Interrogation of Proteostasis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Proteomic Profiling Illuminates Engagement of Higher Order CDKs for an Optimized CDK9 Inhibitor"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Chemical Approaches to Unravel Mechanisms and Functions of Novel Histone Modifications"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Probes and Leads: Optimization and Application
7:30 pm - 8:00 pm
"Attenuating Oncogenic Transcription with Small Molecules"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"High-Throughput Behavior Based Neuroactive Drug Discovery in the Zebrafish"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"A Chemical Biology Approach to Model a Rare Neurodegenerative Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Small-Molecule TEAD-Yap Covalent Antagonists"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Application of Omics to Decipher Biology
9:00 am - 9:30 am
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Activity Landscapes of Tumor Cell Lines Reveal Mechanisms of Drug Sensitivity and Resistance"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Using Funky Fragmentation to Build New Chemoproteomic Assays"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Activity-Based Sensing and Activity-Based Proteomics Approaches to Studying Metal and Redox Biology"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Identification of p300/CBP as the Cellular Target of the Small Molecule 'BRD16' Following a Phenotypic Screen"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Pathways and Platforms Spanning Space, Time and Reactivity in the Proteome"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Synthetic Biology Approaches to Study and Control the Transcriptome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Looking for Drugs in Unconventional Places
7:30 pm - 8:00 pm
"Microbiome and Natural Products"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Deciphering the Human Microbiota Using Chemistry"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Mapping of Immunomodulatory Receptor Protein Interactions via Photoactivation-Based Proximity Labeling of the Cell Surface"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Technologies in Translation Chemical Biology
9:00 am - 9:30 am
"Chemical Probes of Intracellular Target Occupancy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Reimagining Druggability Using Chemoproteomic Platforms"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Chemical Biology Tools for Target Identification and Validation"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"IRAK4 Degradation with Orally Active Compounds in MYD88 Driven Diseases"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Applications of Clickable Chemical Biology in Drug Discovery"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Peptide-Based Tools to Interrogate Quorum Sensing Signaling in Bacteria"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"RNA as a Drug Target and Material for Nanotechnology"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Fluorogenic Probes for Visualizing Biology"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Chemical Probing of Coding and Non-Coding RNA Biology"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Chemical Tools that IMPACT Lipid Signaling"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
