Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Enabling Technologies
Discussion Leader: Wenjing Wang (University of Michigan, United States)
7:40 pm - 8:10 pm
Lara Mahal (University of Alberta, Canada)
"Overturning the Paradigm, What Systems Approaches Tell us About Non-Coding RNA and Glycosylation"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Matthew Francis (University of California, Berkeley, United States)
"Making Protein-Protein Conjugates Using Enzymatic Oxidative Coupling Reactions"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Sloan Devlin (Harvard Medical School, United States)
"Microbial Mechanisms in Bariatric Surgery"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Robert Grams (University of Virginia, United States)
"Probing Proteoforms in a Oncogenic Pathway with Tyrosine-Reactive Chemistry"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycobiology in Human Health
Discussion Leader: Tania Lupoli (New York University, United States)
9:00 am - 9:10 am
Darci Trader (Purdue University, United States)
"Harnessing the Activity of the Immunoproteasome as a Prodrug Mechanism"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Charlie Fehl (Wayne State University, United States)
"Spatiotemporal Strategies for Tracking Glycoprotein Functions in Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
M.G. Finn (Georgia Institute of Technology, United States)
"Bioorganic Adventures in Carbohydrate and Peptide Immunology"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Yael David (Memorial Sloan Kettering Cancer Center, United States)
"Revealing Cancer-Associated Epigenetic Events using Novel Chemical Tools"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Kamil Godula (University of California, San Diego, United States)
"Chemical Tools for Engineering Glycan Interactions at the Cell-Matrix Interface"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Mia Huang (Scripps Research, United States)
"Precision Chemical Tools to Probe Glycoconjugate Structure and Interactions"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
General Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Louise Charkoudian (Haverford College, United States) and Alexis Komor (University of California, San Diego, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microfluidics for High-Throughput Biology
Discussion Leader: Alix Chan (Genentech, United States)
7:30 pm - 7:55 pm
Brian Paegel (University of California, Irvine, United States)
"Activity-Based and Phenotypic DNA-Encoded Library Screening"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Adam Abate (University of California, San Francisco, United States)
"Metabolic Biosensing to Discover Novel Enzyme Catalysis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Daniel Holland-Moritz (Merck & Co., United States)
"Microfluidic Droplet Sorting with Mass Spectrometry Enables Rapid Directed Evolution"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Polly Fordyce (Stanford University, United States)
"Microfluidics for High-Throughput, Quantitative Enzymology"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular Imaging and Engineering
Discussion Leader: Stephen Fried (Johns Hopkins University, United States)
9:00 am - 9:25 am
David Savage (University of California, Berkeley, United States)
"High-Throughput Approaches for Engineering CRISPR-Cas Proteins"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Paul Richardson (AbbVie, United States)
"Modified Chemical Probes for Assays and Chemical Biology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Christina Woo (Harvard University, United States)
"Discovery of a Degron for the Thalidomide Binding Domain of Cereblon"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Louise Charkoudian (Haverford College, United States)
"Unlocking Polyketide Synthases for Access to Expanded Chemical Diversity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Christopher Chang (University of California, Berkeley, United States)
"Transition Metal Signaling: Shining a Light on the Elements of Life"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Jefferson Chan (University of Illinois at Urbana-Champaign, United States)
"Chemical Approaches to Manipulate Sound for in vivo Imaging Applications"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetics and Epitranscriptomics
Discussion Leader: Alexis Komor (University of California, San Diego, United States)
7:30 pm - 7:55 pm
Heather Hundley (Indiana University, United States)
"Uncovering a Molecular Mechanism used to Regulate A-to-I RNA Editing during Neural Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Chuan He (University of Chicago, United States)
"Transcription Regulation by RNA Methylation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Ralph Kleiner (Princeton University, United States)
"Activity-Based probes for an Ancient Family of RNA Modifying Enzymes"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Jia Niu (Boston College, United States)
"Development of a Xenobiotic Nucleic Acid Platform Capable of Post-Transcriptional Functionalization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Brian Liau (Harvard University, United States)
"Chemical Genomics to Illuminate Mechanisms of Transcriptional Targets"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acid Technologies
Discussion Leader: Kathryn Mouzakis (Loyola Marymount University, United States)
9:00 am - 9:25 am
Martin Eastgate (Bristol Myers Squibb, United States)
"Enabling Innovation for Complex Pharmaceuticals"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Jonathan Sczepanski (Texas A&M University, United States)
"Mirror-Image Oligonucleotides: Tools, Applications, and Caution"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Joshua Kritzer (Tufts University, United States)
"Measuring Cytosolic and Nuclear Penetration of Nucleic Acid Therapeutics"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Marino Resendiz (University of Colorado Denver, United States)
"Using Small Aromatic Rings at the C2'-O-Position of RNA to Target Proteins and Build Distinct Supramolecular RNA-Frameworks"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Andrea Rentmeister (University of Münster, Germany)
"Beyond Methylation: Controlling Methyltransferase Activity and Target Sites"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Yana Cen (Virginia Commonwealth University, United States)
"Small Molecule Approach to Study Human Sirtuins"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Computational Chemical Biology
Discussion Leader: Abhishek Singharoy (Arizona State University, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Alemayehu Gorfe (University of Texas Health Science Center at Houston, United States)
"Membrane Binding and Druggability of Lipid-Modified Small GTPases"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Peter Kutchukian (Novartis Institutes for Biomed. Research, United States)
"Cheminformatics Hit Finding Strategies and Tool Development"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Abhishek Singharoy (Arizona State University, United States)
"Deep Learning of Peptidomes and Glycomes to Distinguish Between Host and Pathogens"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptides and Peptidomimetics
Discussion Leader: Abigail Knight (University of North Carolina at Chapel Hill, United States)
9:00 am - 9:25 am
Monika Raj (Emory University, United States)
"Chemical Tools for Selective Modification of Peptides and Proteins"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Olalla Vázquez (Philipps-Universität Marburg, Germany)
"Photoswitches as Optochemical Tools for Gene Expression"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Liron Bar-Peled (MGH Cancer Center and Harvard Medical School, United States)
"Identification of Chemotherapy Targets Reveals a Nuclear-to-Mitochondria ROS Sensing Pathway"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Annelise Barron (Stanford University, United States)
"One Ellipsoid to Rule Them All — Cathelicidin-Mimickilng Peptoids that are Antiviral, Antibacterial & Antifungal and Well-Tolerated in the Lung"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Amelia Fuller (Santa Clara University, United States)
"Expanding Molecular Recognition Functions of Peptoids"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Stephen Fried (Johns Hopkins University, United States)
"Secretion-Catalyzed Assembly of Peptide Biomaterials on a Bacterial Membrane Surface"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Wenjing Wang (University of Michigan, United States)
"Optogenetic Sensors and Tools for Studying Brain Signaling and Neurodegenerative Diseases"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Discovery by Mass Spectrometry
Discussion Leader: Lars Plate (Vanderbilt University, United States)
7:30 pm - 7:55 pm
Alan Saghatelian (Salk Institute for Biological Studies, United States)
"Discovering and Characterizing Mammalian Microproteins"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Vishal Rai (Indian Institute of Science Education and Research Bhopal, India)
"Chemical Technologies for Precision Engineering of Proteins"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Markus Schirle (Novartis Institutes for Biomedical Research, United States)
"Chemoproteomics Applications for Target Deconvolution, Mapping of Druggable Pockets and Exploration of Novel Modalities"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Pamela Chang (Cornell University, United States)
"Deconvoluting Host-Gut Microbiota Co-Metabolism"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
