Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Translational Chemical Biology
7:40 pm - 8:10 pm
"The Rise of Molecular Glues and Bifunctional Compounds"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Pirating Nature for New Engineered Proteins"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Natural Product Derivatives as Powerful Tools to Study Translation"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeted Protein Degradation and Induced Proximity
9:00 am - 9:25 am
"Rational and Systematic Surveys for Novel Glue Discovery"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Leveraging Proximity-Biology for Innovative Drug Discovery"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Chemical Biology Tools for Hematologic Disorders"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"A Structure-Based Approach to Drugging RNA with Small Molecules"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Highly Efficient Endosomal Escape of Proteins, Nucleic Acids, and Their Complexes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Bioorthogonal Small-Molecule Probes for Live Cell Imaging"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Using Chemical Biology for Serendipitous Discoveries
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Molecular Logic of Client-Selective Sec61 Inhibition"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Stabilizing Native Protein-Protein Interactions with Molecular Glues"
10:00 am - 10:05 am
Discussion
10:05 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Chemical Control of Metabolism by Amino Acid-Derived Metabolites"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Targeting Gastrointestinal Cancers with Small-Molecule Inhibitors of ALDH1B1"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Unbiased Approaches to Find Chemical Probes of Chromatin Regulators"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Genetically Encoded Photocatalytic Protein Labeling Enables Spatially-Resolved Profiling of Intracellular Proteome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acids Chemical Biology
7:30 pm - 7:55 pm
"Quantitative Chemical Imaging of Organelles"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Structure-Based Discovery of New Functions in Large RNAs"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Riboswitching the Light on Small Molecule Activity in Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Targeting RNA Using Artificial Intelligence and Experiment"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Multi-Omic Approaches to Stratify the Cysteinome"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
"Chemical and Computational Proteomics for Functional Target Discovery"
10:55 am - 11:00 am
Discussion
11:00 am - 11:15 am
"Host-Produced, Bacterially Modified Gut Metabolites"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"A Chemical Biology-Based Approach to Study and Modulate the cGAS-STING Pathway"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Chemical Tools for Uncovering New Redox Biology at the Host–Microbe Interface"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Poster Previews
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Chemical Glycobiology of Mammalian Cell Signaling"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Decoding the Structures and Roles of the Gut Microbiota-Derived Peptidoglycan Fragments in the Host"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Activation of Prokaryote-Specific Sugars for Incorporation into Bacterial Cell Surfaces"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
New Therapeutic Modalities and Emerging Technologies
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Chemical Approaches to Drug and Study Chromatin Machinery"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Engineering the Ribosome to Synthesize New Sequence-Defined Polymers"
10:00 am - 10:05 am
Discussion
10:05 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Protein Editing Using Small Molecules?"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"SuTEx Chemistry: Applications for Chemical Biology and Protein Ligand Discovery"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Virus-Assisted Directed Evolution and Mutation Profiling in Mammalian Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Chemical Biology
7:30 pm - 7:55 pm
"Polymerization Inducing Chimeras: If You Can't Beat Them, Join Them"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Ultra Large Make-On-Demand Library Docking: Is Bigger Always Better?"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"AlphaFold for Docking-Ready Structures and Their Applications"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"At the Dawn of Insights - Hunting for Compounds with Novel MoAs from Existing Cellular HTS Data with Gray Chemical Matter"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure