Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Breakthroughs in Glycoscience
7:40 pm - 8:10 pm
"Research at the Interface of Chemistry and Neurobiology"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Chemical Biology to Elucidate the Biological Roles of Carbohydrates"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Chemical Tools to Track Carbohydrates in Life Processes and Oncogenesis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Biology and Targeting of Nucleic Acids
9:00 am - 9:20 am
"Biomimetic Chemistry and the World of RNA Therapeutics"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Regulation of MicroRNA Processing"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"RNA Chemical Probing Reagents and Protein Amino Acids: A Double-Edged Sword"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Leveraging an RNA-Targeting Platform for the Discovery of Cell-Active c-MYC mRNA-Binding Small Molecules"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Integrated Methods to Visualize Structural Dynamics of Multistate RNAs"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Small Molecule Inhibitors that Selectively Block DNA-Binding by Trypanosoma Bruce Replication Protein A1"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tools for Epigenetic and Epitranscriptomic Regulation
7:30 pm - 7:50 pm
"Mechanism-Based Approaches for Targeting Histone Reader Proteins"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Building on Natural Product Motifs for Cyclic Peptide Inhibitor Discovery"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Profiling Adenine Methylation in the Mammalian Genome and Transcriptome"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Screening and Characterization of Cyclic Peptide Inhibitors of NRAS-Q61R and CRAF Interaction"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Advancements in High Throughput Targeted Proteomics: The Development and Application of a HiTChem Platform for Multiplexed Target Detection using a Fully Functionalized Photofragment Library"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chemical Biology of Infectious Disease
9:00 am - 9:20 am
"Collaborations with Nature for Antimicrobial and Natural Products Discovery"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Investigating an Essential Complex In Conjugative Plasmid Transfer"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Inhibiting the Immune Systems of Bacteria"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Strategies for Accessing Inner Membrane Antibiotic Targets in Gram-Negative Bacteria"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Chemical Tools to Detect, Discover, and Disrupt Sugars on Pathogenic Bacteria"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Exploration of Immunophilin Recruitment to Inhibit RNA Translation"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"High-Throughput Methods to Measure RNA Folding Thermodynamics in Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Synthesis and Anti-Microbial Activity of Phenylpropanoid Glycosides"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bioorthogonal Reaction and Tagging Applications
7:30 pm - 7:50 pm
"Gut Feeling: Illuminating Atypical Stress-Sensing Mechanisms in the Gut Empowers New Therapeutic Opportunities"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"No-Wash Fluorogenic Assays Enabled by Engineered HaloTags"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"BHoPAL : Baylis Hillman-Orchestrated Protein Aminothiol Labelling"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"TrogoTACs: Bispecific Chimeras for Targeted Protein Transfer"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Quantitative Target Engagement in Whole Blood with the Cellular Thermal Shift Assay (CETSA)"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Tool Development in Chemical Biology
9:00 am - 9:20 am
"The Development of Chemical Pathways to Probe Fundamental Biology"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"RAPID: Photoaffinity-Based High Throughput Ligand Discovery in Cells"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Minimal Protein Affinity Tags"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Advances in Chemical Bioproduction"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Protein-Protein Interactions at C-Termini: Regulation of Protein Stability"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Chemical Biology to Direct Dopamine and Serotonin Receptors: Signaling and Proteomic Investigations"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Tools in Toxicology
7:30 pm - 7:50 pm
"Naturally and Synthetically Modified Nucleosides and Nucleotides in the Determination of Disease Etiology"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Mapping the Chemistry of Genotoxicity"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Chemoproteomic Selectivity Profiling of Clinical BTK Inhibitors Reveals an Off-Target with Potential Implications for DILI"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Free Cysteine Profiling Confirmed STING Target Engagement and Identified Potential Covalent Off-Targets for a Novel STING Inhibitor"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"SIRT6 Activation by DNA Strand Breaks"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Advances and Applications in Mass Spectrometry
9:00 am - 9:20 am
"Inter-Organ Communication through Lipid Derived Metabolites"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Activity-Based Protein Profiling: Using Mass Spectrometry to Find and Study Enzymes in Microbiomes"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"An 'Omics Approach to Drug Discovery"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Covalent Drug Discovery Strategies to Tackle Challenging Cancer Targets"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Aromatic Ynamines: New Bio-Orthogonal Tools for Bioconjugate Synthesis and Activity-Based Protein Profiling"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Small-Molecule Ligand-Guided µMap for Investigating Target Interactomes"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Precision Chemistry and Activity-Based Proteomics for Posttranslational Control of Protein Function"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"HINT1 Inhibitors as Selective Modulators of MOR-NMDAR Cross Regulation and Analgesia"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptides as Tools to Understand Biology
7:30 pm - 7:50 pm
"Unraveling the Signaling of Endogenous Cell-Cell Signaling Peptides"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Two Bites at the Apple: Molecular Design and Repair of Peptide Therapeutics"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Foldamers as Tools to Influence Chemistry and Society"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Sulfonyl Fluoride Tropanes as Electrophilic Probes"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Leveraging Antibody Recognition and Peptide Chemistry for Targeting Cell Surface Receptors"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
General Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
