Sunday evening:
FRONTIERS OF ENZYMOLOGY
- Christopher T. Walsh (Harvard Medical School): Molecular Studies on Bacterial Resistance to Vancomycin
- Gregory A. Petsko (Brandeis): Crystallography and mechanism: where are we and where are we going?
Monday morning:
RADICAL ENZYMES
- JoAnne Stubbe (MIT): Radicals, Radicals, and Yet More Radicals
- John Lipscomb (Minnesota): Intermediates in the Substrate and Oxygen Activation Cycle of Methane Monooxygenase
- Ruma Banerjee (Nebraska): Characterization of Biradical Intermediates on Methylmalonyl-CoA Mutase
- Perry A. Frey (Wisconsin): Lysine 2,3-amino mutase: characterization of substrate-based radical intermediates
Monday evening:
ENZYME MECHANISMS
- Duilio Arigoni (ETH): Recent Discoveries in the Isoprenoid Biosynthetic Pathway
- Barbara Imperiali (Cal Tech): Protein Glycosylation: Specificity and Function
- Chris Abell (Cambridge): Mechanistic Studies on Biosynthetic Enzymes
Tuesday morning:
NATURAL PRODUCT ENZYMOLOGY/GENETICS
- Chaitan Khosla (Stanford): Non-Template Based Multi-Enzyme Assemblies: ThePolyketide Synthase Example
- Mohamed A. Marahiel (Marburg): Biosynthesis, Regulation and Design of Peptide Antibiotics
- Toni N. Kutchan (Munich): New Insights into the Mechanisms of the Enzymes of Isoquinoline Alkaloid Biosynthesis
- C. Dale Poulter (Utah): Farnesyl Diphosphate Synthase. Structure and Function
Tuesday evening:
SIGNAL TRANSDUCTION
- Susan Taylor (UCSD): Structure and function relationships in the cAMP-dependent protein kinase
- Zhong-Yin Zhang (Einstein): Mechanism of Catalysis by Protein-Tyrosine Phosphatases
- Gregory L. Verdine (Harvard): Keepers of the Code: Structural and Mechanistic Studies on Proteins that Decorate and Mend the Genome
Wednesday morning:
REDOX ENZYMOLOGY
- Gerald T. Babcock (Michigan State): Water/Oxygen Metabolism in Metalloprotein Active Sites
- Shinya Yoshikawa (Himeji Institute): Structure of cytochrome c oxidase
- Dennis H. Flint (DuPont): Initial Steps in the Synthesis of Fe-S Clusters
Wednesday evening:
ENZYMES IN DISEASE
- Peter T. Lansbury, Jr. (MIT): Molecular Mechanism of Amyloid Formation in Neurodegenerative Diseases
- David Bramhill (Merck): The Role of the Tubulin-Like FtsZ Protein as a Component of Bacterial Cell Division Machine
- Mark Levy (Smith Kline Beecham): Cathepsin O: A Novel Cysteine Protease Selectively Expressed in Human Osteoclasts
Thursday morning:
EVOLUTION OF CATALYSIS
- Thomas Scanlon (UCSF): Enzyme Design and Evolution
- David Bartell (Whitehead Institute): New Ribozymes from Random RNA Sequences
- Short talks (3) selected from posters
Thursday evening:
PROTEIN ENGINEERING
- Charles Craik (UCSF): Engineered Metalloregulation of Proteolytic Activity
- William F. DeGrado (DuPont-Merck/Penn): De Novo Protein Design
|
