| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 4:00 pm | Co-chairs reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CRYSTALS IN ACTION |
| Discussion Leader: Brian J. Bahnson (University of Delaware) |
| 7:30 pm - 8:30 pm | Stephen K. Burley (Structural GenomiX)
"Structural genomics of antibiotic resistance enzymes" |
| 8:30 pm - 9:30 pm | Manuel Navia (Essential Therapeutics)
"A Crystallographic Study of the Mechanism of Action of Thermolysin in the Commercial Scale Synthesis of the Artificial Sweetener Aspartame" |
| MONDAY |
| 7:30-8:30 am | Breakfast |
| 8:45 am | Photo |
| 9:00 am - 12:30 pm | COFACTORS AND METABOLIC PATHWAYS |
| Discussion Leader: Shelley Copley (University of Colorado) |
| 9:00 am - 9:45 am | Robert H. White (University of Illinois)
"Biosynthesis of Coenzymes in the Archaea" |
| 9:45 am - 10:30 am | Hung-wen (Ben) Liu (University of Texas at Austin)
"Mechanistic Studies of Novel C-O Bond Formation and Cleavage Reactions" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Suzanne Walker (Princeton University)
"Peptidoglycan Biosynthesis and Its Inhibition" |
| 11:45 am - 12:30 pm | Lawrence Wackett (University of Minnesota)
"Evolution of a Metabolic Pathway for S-triazine Herbicides" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:45 pm | SIGNAL TRANSDUCTION |
| Discussion Leader: Wilfred van der Donk (University of Illinois) |
| 7:30 pm - 8:15 pm | Ann Stock (Rutgers University)
"Phosphotransfer mediated signal transduction in bacteria" |
| 8:15 pm - 9:00 pm | John Denu (Oregon Health and Science University)
"Molecular Mechanisms of cell signaling through reversible protein modifications" |
| 9:00 pm - 9:45 pm | Philip Cole (The Rockefeller University)
"Chemical and Structural Approaches to Inhibition and Activation of Protein Phosphorylation" |
| TUESDAY |
| 7:30-8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ENZYME MECHANISMS |
| Discussion Leader: Tadhg Begley (Cornell University) |
| 9:00 am - 9:45 am | Eric Furfine (Regeneron Pharmaceuticals)
"1) Mechanism of resistance to HIV protease inhibitors 2) Discovery GW908, a prodrug of Amprenavir" |
| 9:45 am - 10:30 am | Vernon Anderson (Case Western University)
"Isotopic analysis of the interactions between enzymes and substrates" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 pm | Stephen G. Withers (University of British Columbia)
"Glycosidases and lyases: two approaches to glycosidic bond cleavage" |
| 11:45 am - 12:30 pm | Jovita Marcinkeviciene (Bristol Meyers-Squibb Pharmaceuticals)
"Role of mechanistic studies in drug discovery: Example of bacterial enoyl-ACP reductase" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:45 pm | PROTEIN DYNAMICS |
| Discussion Leader: Carla Mattos (North Carolina State University) |
| 7:30 pm - 8:15 pm | Dorthee Kern (Brandeis University)
"Enzymes in Action in the NMR Tube" |
| 8:15 pm - 9:00 pm | Ilme Schlichting (Max Planck Institute of Molecular Physiology)
"Crystallographic Structure Determination of Unstable Species" |
| 9:00 pm - 9:45 pm | Jane Dyson (Scripps Research Institute)
"Dynamics of Folded and Unfolded Proteins" |
| WEDNESDAY |
| 7:30-8:30 am | Breakfast |
| 9:00 am - 12:30 pm | METALLOENZYMES |
| Discussion Leader: Eileen Jaffe (Fox Chase Cancer Institute) |
| 9:00 am - 9:45 am | George McLendon (Princeton University)
"Electron Transfer in Proteins" |
| 9:45 am - 10:30 am | David E. Ash (Temple University)
"Catalysis on Binuclear Mn(II) Centers: New Physiologic Roles for Arginase" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Poster Talk I (TBA) |
| 11:30 am - 12:00 pm | Poster Talk II (TBA) |
| 12:00 am - 12:30 pm | Poster Talk III (TBA) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:45 pm | ENZYMES |
| Discussion Leader: Perry Frey (University of Wisconsin) |
| 7:30 pm - 8:15 pm | Dan Quinn (University of Iowa)
"Structure-Activity Relationships and Molecular Recognition in Cholinesterase Catalysis" |
| 8:15 pm - 9:00 pm | Paul Cook (University of Oklahoma)
"Regulation of the Ascaris suum NAD-Malic Enzyme" |
| 9:00 pm - 9:45 pm | James T. Stivers (Johns Hopkins University School of Medicine)
"Probing the Limits of Electrostatic Catalysis by Uracil DNA Glycosylase Using Transition-State Mimicry and Mutagenesis" |
| THURSDAY |
| 7:30-8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NEW APPROACHES |
| Discussion Leader: Patricia Babbitt (Univ. of California, San Francisco) |
| 9:00 am - 9:45 am | Paul Carey (Case Western University)
"Interactions and reactivities of single groups in enzyme substrate crystals by Raman microscopy" |
| 9:45 am - 10:30 am | Francine Perler (New England Biolabs)
"Intein-mediated protein splicing: variations on a theme" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Ben Cravatt (Scripps Research Institute)
"Mapping Enzyme Active Site Space and Reactivity in Complex Proteomes" |
| 11:45 am - 12:30 am | Gregory D. Reinhart (Texas A&M University)
"Disentangling the Web of Allosteric Interactions in a Tetrameric Enzyme" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Banquet |
| 7:30 pm - 9:30 pm | NEW FRONTIERS |
| Discussion Leader: Joseph J. Villafranca (Bristol-Myers Squibb) |
| 7:30 pm - 8:30 pm | Al Mildvan (Johns Hopkins University)
"Structure and Mechanism of the MutT Pyrophosphohydrolase and its Homologs" |
| 8:30 pm - 9:30 pm | Martin Karplus (Harvard University)
"How Enzymes Function: Activation Energy and Dynamics" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
