| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 4:30 pm | Co-chairs reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | FROM ENZYMOLOGY TO CELL BIOLOGY |
| Discussion Leader: Richard Armstrong (Vanderbilt University) |
| Greg Verdine (Harvard University)
"Enzymatic Recognition and Repair of Damaged DNA" |
| Hirotada Mori (NARA Institute of Science and Technology)
"Understanding Pathway Reactions in the Cell: An Approach from Functional Genomics" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | RADICALS IN ENZYMOLOGY |
| Discussion Leader: Squire Booker (Pennsylvania State University) |
| Peter Tipton (University of Missouri)
"Urate Oxidase and Ureide Metabolism: New Enzymes, No Coenzymes, and a Revised Metabolic Pathway" |
| Poster Talk I (TBA) |
| 10:05 am - 10:35 am | Coffee Break |
| Poster Talk II (TBA) |
| Juan Carlos Fontecilla-Camps (Institut de Biologie Structurale Jean-Pierre Ebel)
"Crystal Structures of Three Time-Dependent Productive Pyruvate: Pyruvate-Ferredoxin Oxido-Reductase Complexes and of a Pyruvate-Dependent, Oxygen-Inhibited Form of the Enzyme" |
| Joanne Stubbe (Massachusetts Institute of Technology)
"Ribonucleotide Reductases: Radical Initiation by Long Range Proton Coupled Electron Transfer?" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ENZYME STRUCTURE AND FUNCTION |
| Discussion Leader: Sean Taylor (Ohio State University) |
| Chaitan Khosla (Stanford University)
"Protein-Protein Interactions in Polyketide Synthases" |
| Jennifer Harris (Novartis Research Foundation)
"PNA-encoded Small Molecules - A Function-Based Approach to Proteomics" |
| Lorena Beese (Duke University)
"Observing DNA Replication Errors in a Catalytically Active
Polymerase Crystal" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | METABOLIC PATHWAYS |
| Discussion Leader: Sheryl Tsai (University of California, Irvine) |
| Poster Talk III (TBA) |
| Ben Shen (University of Wisconsin)
"Enediyne Natural Products: Biosynthesis and Prospect towards Engineering Novel Antitumor Agents" |
| 10:05 am - 10:35 am | Coffee Break |
| Poster Talk IV (TBA) |
| Andrei Osterman (Integrated Genomics)
"Enzymes in Co-Enzyme Metabolic Pathways: A Comparative Genomics
Approach |
| Christian Raetz (Duke University)
"Enzymatic Synthesis of Lipid A in Gram-Negative Bacteria" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NEW APPROACHES FOR UNDERSTANDING FUNCTION AND MECHANISM |
| Discussion Leader: Thomas Harris (University of Miami) |
| Brian Shoichet (University of California, San Francisco)
"A Specific Mechanism for Non-Specific Inhibition" |
| Neil Kelleher (University of Illinois, Urbana-Champaign)
"Targeted Analysis and Discovery of Enzyme Post-Translational
Modifications" |
| Pehr Harbury (Stanford University)
"Footprinting Enzymes: Structure and Dynamics" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | COMPUTATIONAL APPROACHES FOR UNDERSTANDING FUNCTION AND MECHANISM |
| Discussion Leader: Patricia Babbitt (Univ. of California, San Francisco) |
| Jacquelyn Fetrow (Wake Forest University)
"Combining Chemical and Computational Approaches for Proteome Analysis" |
| Mark Gerstein (Yale University)
"Prediction of Protein Function on a Genome Scale" |
| 10:30 am - 11:00 am | Coffee Break |
| Peter Karp (SRI International)
"The MetaCyc Metabolic Pathway Database" |
| Zoltan Oltvai (Northwestern University)
"Organization of Cellular Networks" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ENZYME SUPERFAMILIES AND EVOLUTION |
| Discussion Leader: Valerie de Crecy-Lagard (Scripps Research Inst.) |
| Steven Ealick (Cornell University)
"Evolution of Structure and Function within a Family of Nucleoside Cleaving Enzymes" |
| Shelley Copley (University of Colorado, Boulder)
"Recruitment of Proteins to Serve New Functions in an Evolving Metabolic Pathway" |
| Charles Craik (University of California, San Francisco)
"Molecular Recognition in Serine Proteases" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | FROM ENZYMOLOGY TO CELL BIOLOGY II |
| Discussion Leader: Kapila Ratnam (GlaxoSmithKline) |
| Roger Brent (Molecular Sciences Institute)
"The Alpha Project and the Dream of a Predictive Biology" |
| Poster Talk V (TBA) |
| Poster Talk VI (TBA) |
| 10:25 am - 11:00 am | Coffee Break |
| Dewey McCafferty (University of Pennsylvania)
"Connections Between Peptidoglycan Biosynthesis and Cell Wall Protein
Attachment in Gram Positive Bacteria" |
| Pat Casey (Duke University)
"Enzymology and Biology of Post-Prenylation Processing of CaaX
Proteins" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Banquet |
| 7:30 pm - 9:30 pm | FRONTIERS IN ENZYMOLOGY |
| Discussion Leader: Frank Raushel (Texas A&M University) |
| John Gerlt (University of Illinois, Urbana-Champaign)
"Enzyme Superfamilies and Suprafamilies" |
| Cathy Drennan (Massachusetts Institute of Technology)
"Life on Carbon Monoxide: Structure of the Machine" |
| Stephen Ragsdale (University of Nebraska)
"Life on Carbon Monoxide: the Machine" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
