| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Control of Catalytic Activity |
| Discussion Leader: John Gerlt (University of Illinois) |
| 7:30 pm | Welcome |
| 7:45 pm - 8:30 pm | Michael Marletta (University of California, Berkeley)
"Ligand discrimination in hemoprotein sensing domains and the selective control of catalytic activity" |
| 8:30 pm - 9:15 pm | Ruma Banerjee (University of Nebraska)
"Mapping Motions in a Modular Protein: Allosteric Regulation of Human Cystathionine ß-synthase" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | RNA: Enzyme and Substrate |
| Discussion Leader: Dieter Söll (Yale University) |
| 9:00 am - 9:45 am | Barry Cooperman (University of Pennsylvania)
"Dynamics of ribosome catalysis" |
| 9:45 am - 10:30 am | Dirk Iwata-Reuyl (Portland State University)
"Mechanistic studies of an enzyme involved in tRNA modification" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Peter Linsley (Rosetta Inpharmatics)
"Microarrays and RNAi mechanisms" |
| 11:45 am - 12:30 pm | Tamara Hendrickson (Johns Hopkins University)
"Novel aminoacyl-tRNA synthetases as windows into evolution" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Enzymes as Drug Targets |
| Discussion Leader: Richard Armstrong (Vanderbilt University) |
| 7:30 pm - 8:15 pm | Stewart Fisher (Astra-Zeneca)
"The hunt for H. pylori-specific antibiotics: MurI as a case study" |
| 8:15 pm - 8:35 pm | T.K. Harris (University of Miami)
"Discovering New Drug Targeting Sites on Flexible Multi-Domain Protein Kinase" |
| 8:35 pm - 9:20 pm | Peter Tonge (University at Stony Brook)
"Menaquinone and mycobactin biosynthesis: mining the magic mountain for a TB drug" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cofactors and Metals |
| Discussion Leader: Colin Thorpe (University of Delaware) |
| 9:00 am - 9:45 am | Adelbert Bacher (Technische Universität München)
"Biosynthesis of Isoprenoids" |
| 9:45 am - 10:30 am | Dennis Dean (Virginia Tech)
"Substrate interaction with the nitrogenase iron-molybdenum cofactor" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Nigel Richards (University of Florida)
"Enzymology of Oxalate Catabolism" |
| 11:45 am - 12:05 pm | Holly Ellis (Auburn University)
"Novel Mechanistic Features of a Flavin Transfer-dependent Monooxygenase" |
| 12:05 pm - 12:25 pm | Elizabeth Trimmer (Grinnell College)
"Aspartate 120 of Escherichia coli Methylenetetrahydrofolate Reductase: Evidence for Major Roles in Folate Binding and Catalysis, Minor Role in Flavin Reactivity" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Enzyme Mechanism |
| Discussion Leader: Ronald Kluger (University of Toronto) |
| 7:30 pm - 8:15 pm | Paul Berti (McMaster University)
"Transition state analysis of O- and N-glycoside chemistry: doing it the easy way and the hard way" |
| 8:15 pm - 8:35 pm | Andrea Hadfield (University of Bristol)
"Structural elucidation of the catalytic cycle of Lactate Dehydrogenase from Plasmodium Falciparum" |
| 8:35 pm - 9:20 pm | James Naismith (University of St. Andrews)
"The mechanism of F and Cl incorporation in bacteria" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Phosphorylation, Dephosphorylation, and Signaling |
| Discussion Leader: Kevin Dalby (University of Texas) |
| 9:00 am - 9:45 am | Johannes Rudolph (Duke University)
"Cdc25: the enzymology of a protein phosphatase" |
| 9:45 am - 10:30 am | Albert S. Mildvan (Johns Hopkins School of Medicine)
"Kinetic and structural studies of the mechanisms of nudix hydrolases" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Karen Anderson (Yale University)
"Temporal Resolution of Protein Signaling Events" |
| 11:45 am - 12:30 pm | John Richard (University at Buffalo)
"Enzyme-Like Small Molecule Catalysts of Phosphate-Diester Cleavage" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Carbohydrates |
| Discussion Leader: Ben Liu (University of Texas) |
| 7:30 pm - 8:15 pm | Gideon Davies (University of York)
"Glycosidase substrate distortions and transition-state mimicry" |
| 8:15 pm - 8:35 pm | Walter Fast (University of Texas at Austin)
"Mechanism and Inhibition of Dimethylargininase" |
| 8:35 pm - 9:20 pm | Vern Schramm (Albert Einstein School of Medicine)
"Chemistry and biology lessons from transition state analogues" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Emerging Systems and Methods |
| Discussion Leader: Wilson A. Francisco (Arizona State University) |
| 9:00 am - 9:45 am | Homme Hellinga (Duke University)
"Computational enzyme design" |
| 9:45 am - 10:30 am | Joseph Krzycki (Ohio State University)
"Biogenesis and function of pyrrolysine, the 22nd amino acid" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Kenny Wong (Merck)
"The application of chemical and genetics tools to find new medicines: case studies at Merck" |
| 11:45 am - 12:30 pm | Wilfred van der Donk (University of Illinois)
"Posttranslational modifications during lantibiotic maturation" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Frontiers in Enzymology |
| Discussion Leader: George Kenyon (University of Michigan) |
| 7:30 pm - 8:30 pm | Rowena Matthews (University of Michigan)
"Cobalamin-dependent and independent methionine synthases: is there more than one way to skin a cat?" |
| 8:30 pm - 9:30 pm | Perry Frey (University of Wisconsin)
"Lysine 2,3-aminomutase: structure and the mechanism of SAM cleavage" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
