There will be a strong focus at this conference on the broader biological aspects of enzyme action, the discovery of new enzymatic chemistries and the impact of enzymology in obtaining engineered natural products with interesting biological activity and in environmental bioremediation. Lectures discussing the role of complex co-factors in catalysis, including transition metal clusters, will also be a feature of the meeting. In addition, there will be focused sessions on: (i) the chemical mechanisms by which enzymes activate molecular oxygen, (ii) how substrates are channeled between multiple active sites within complex enzymes, (iii) the chemistry of transition metal and other co-factors, (iv) the role of enzymes in disease and methods for identifying novel drug targets, and (v) studies at the frontiers of enzymology, including methods for enzyme characterization within living cells.