Discovery and Therapeutic Targeting of New Enzyme Reactions and Pathways

This conference highlights the fundamental questions and practical applications that motivate modern enzymology and mechanistic biochemistry. It showcases recently elucidated biological pathways and novel enzyme reactions and mechanisms. It synthesizes current thinking on the pathways by which new enzyme activities evolve and highlights cutting-edge approaches to the discovery and development of novel activities. Consistent, enthusiastic participation by industrial scientists helps to ensure that important enzyme targets for, and state-of-the-art approaches to, development of new drug therapies are brought forward. This year's meeting will include sessions on enzymes in medicine, chromatin remodeling and transcription, nucleic acid enzymology, antibiotic development, pathway discovery, phosphorylation in cell signaling, discovery and design of new activities and inhibitors, principles of enzyme catalysis, and novel reactions and mechanisms.