SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Pathways from Structure to Output |
| Discussion Leader: Nigel Richards (University of Florida) |
7:40 pm - 8:10 pm | Hazel Holden (University of Wisconsin)
"Structural Insights into Novel Deoxysugar Biosynthesis in Bacteria"
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8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Janet Smith (University of Michigan)
"Substrate Activation by Sulfonation - Strange Chemistry in Natural Products Biosynthesis" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | James Broering (Codexis)
"Evolution of Carbonic Anhydrase for Low-Cost Industrial Carbon Capture" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanism of DNA Repair |
| Discussion Leader: Francine Perler (New England BioLabs) |
9:00 am - 9:30 am | Zhihao Zhuang (University of Delaware)
"The Regulatory Role of Ubiquitin in Translesion Synthesis and DUB Inhibitor Discovery" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Maria Spies (University of Iowa)
"Single-Molecule Studies of FeS-Containing DNA Helicases: Kinetics, Conformational Dynamics and Molecular Mechanisms"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Group Photo / Coffee Break |
10:50 am - 11:20 am | Wolf Dietrich Heyer (University of California - Davis)
"Regulation of Recombination by Antirecombination and Anti-Antirecombination"
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11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Cheryl Arrowsmith (University of Toronto)
"Structural and Chemical Biology of the Human Protein Methyltransferase"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Kevin Desai (University of Wisconsin-Madison)
"RtcB Catalyzes the GTP-dependent Ligation of RNA with 3'-phosphate and 5'-hydroxyl Termini" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Assembly and Maintenance of Metallo-Cofactors in Enzymes |
| Discussion Leader: Elizabeth Boon (SUNY-Stony Brook) |
7:30 pm - 8:00 pm | Joan Broderick (Montana State University)
"Radical Mechanisms for Metal Cofactor Biogenesis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | David Barondeau (Texas A&M University)
"Frataxin-Based Regulation of Fe-S Cluster Biosynthesis"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Deborah Zamble (University of Toronto)
"The Nickel Accessory Proteins of the (NiFe)-Hydrogenase Biosynthetic Pathway"
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9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Assigning Function and Targeting Inhibition |
| Discussion Leader: Debra Dunaway-Mariano (University of New Mexico) |
9:00 am - 9:30 am | Steve Almo (Albert Einstein School of Medicine)
"PDB to Pathway: Structure-Guided Discovery of a Novel Metabolite for tRNA Wobble Base Modification" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Fan Fan (GlaxoSmithKline)
"On the Catalytic Mechanism of Human ATP Citrate Lyase"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Stewart Fisher (AstraZeneca R&D Boston)
"Translating Slow-Binding Inhibition Kinetics into Cellular and In Vivo Effects"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Erika Taylor (Wesleyan University)
"Heptosyltransferase I: Exploring Function and Dynamics to Create Better Inhibitors for GT-B Enzymes"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Zhaohui Zhou (Northeastern University)
"Enzymology and Chemistry of Protein Modifications: Methylation and Isoaspartic Acid"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Sonja Lorenz (University of California-Berkeley)
"Specificity Determinants of a Low Affinity Catalyst: Mechanism of Lys11-linked Ubiquitin Chain Formation"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Engineering and Discovery of Pathways |
| Discussion Leader: Tom Meek (GlaxoSmithKline) |
7:30 pm - 8:00 pm | Sven Panke (ETH-Zurich)
"Towards In Vitro Design of Pathways"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Hui Zhou (MIT)
"Refactoring the Bacteriochlorophyll a Biosynthetic Genes from Rhodobacter sphaeroides" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Charles Melancon (University of New Mexico)
"Bioinformatics-Guided Natural Product Drug Discovery"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Catalysis Based on Thiols, Selenium and More |
| Discussion Leader: Lei Li (Indiana University-Purdue University-Indianapolis) |
9:00 am - 9:30 am | Vadim Gladyshev (Harvard Medical School)
"How Selenium Has Altered Our Understanding of Thiol Redox Biology" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Kate Carroll (Scripps Research Institute-Forida)
"Peroxide-Dependent Sulfenylation of the EGFR Catalytic Site Enhances Kinase Activity"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Susan Wang (Washington State University)
"An Unusual Methyl Transfer in Microbial Biosynthesis"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Robert Hondal (University of Vermont)
"The Selenium Paradox: The Chemical Basis for the Use of Selenocysteine in Enzymes"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Antonio Ruzzini (University of British Columbia)
"Investigating the Identity of an Orange-Colored Intermediate and the Mechanism of Substrate Tautomerization by a C-C Bond Hydrolase"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Marcy Hernick (Virginia Tech)
"Examination of the Mechanism of MshB Deacetylase Reveals an Unexpected Role for a Dynamic Tyrosine"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Enzyme and Metabolic Regulation |
| Discussion Leader: Aron Fenton (University of Kansas Medical Center) |
7:30 pm - 8:00 pm | William DeGrado (University of California-San Francisco)
"Design and bacterial response to a new class of nonpeptidic mimics of antimicrobial peptides" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kim Orth (UT Southwestern Medical School)
"Black Spot, Black Death, Black Pearl - The Tales of Bacterial Effectors"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Gerald Carlson (University of Kansas Medical Center)
"Discovery of a New Catalytic Activity for Phosphorylase Kinase, the First Protein Kinase to be Characterized"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Engineering Catalysis and Membranes as an Essential Component of Structure and Activity
|
| Discussion Leader: Mark Hixon (Takeda San Diego) |
9:00 am - 9:30 am | Reinhard Sterner (University of Regensburg)
"Protein Design Elucidates the Relationship Between Structure, Function and Stability of a Metabolic Enzyme"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Margaret Glasner (Texas A&M University)
"Comparative Anatomy of O-Succinylbenzoate Synthase Enzymes"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Josh Wand (University of Pennsylvania)
"The Dark Energy of Proteins Comes to Light: Protein Dynamics & Conformational Entropy in Ligand Binding" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Falk Harnisch (Technische Universitat Braunschweig)
"Electrifying Biotechnology: Enzymatic vs. Microorganisms" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Michelle Chang (University of California-Berkeley)
"Mechanistic Studies of aFluorine-Specific Thioesterase"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Topics in Enzymology |
| Discussion Leader: Frank Raushel (Texas A&M University) |
7:30 pm - 8:15 pm | Richard Armstrong (Vanderbilt University)
"Thiols, Thiol Transferases and the New Enzymology" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Michael Marletta (Scripps Research Institute-California)
"Oxidative Chemistry in the Degradation of Cellulose"
|
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |