SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Frontiers of Structure and Function - Tools for Studies of Complex Systems |
| Discussion Leader: Catherine Drennan (MIT/HHMI) |
7:40 pm - 8:10 pm | Vicki Wysocki (Ohio State University)
"Characterizing protein complexes by ion mobility and surface induced dissociation MS"
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8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Donald Hamelberg (Georgia State University)
"Probing functional dynamics in enzymes using computer simulations"
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8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Francisco Asturias (Scripps)
"Regulation of ribonucleotide reductases through quaternary structure rearrangements"
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9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Catalysis and Regulation in Medicine |
| Discussion Leader: Mark Hixon (Takeda) |
9:00 am - 9:30 am | Tom Meek (GSK)
"The dependence of the rate-limiting step(s) of cathepsin C on amino acid substituents of its peptide substrates"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Ruma Banerjee (University of Michigan)
"Lights, Police and Diseases of B12 Trafficking"
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10:10 am - 10:20 am | Discussion |
10:20 am | Group Photo / Coffee Break |
10:50 am - 11:20 am | Stuart Licht (Sanofi US)
"Mechanistic studies of nicotinamide phosphoribosyltransferase"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Elizabeth Boon (Stony Brook University)
"Nitric oxide regulation of bacterial biofilms"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Aimin Liu (Georgia State University)
"An Enzyme Trio for Partitioning Kynurenine Metabolic Intermediates for NAD Biosynthesis"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Phillip Schwartz (Takeda California)
"Commitment to covalency: an approach to understand and evaluate irreversible inhibitor potency"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Enzymology of Alternative Energy |
| Discussion Leader: Jennifer Dubois (Montana State University) |
7:30 pm - 8:00 pm | Rolf Thauer (MPI Marburg)
"Flavin-based electron bifurcation: a novel mechanism of energy coupling in anaerobes"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Anne Jones (Arizona State University)
"Defining directionality and aerotolerance of soluble, multimeric [NiFe]-hydrogenases: How do you make a redox enzyme run backwards?"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Markus Ribbe (UC Irvine)
"Hydrocarbon formation by nitrogenases"
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9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Mechanisms of Complex Biosynthetic Transformations |
| Discussion Leader: Katherine Ryan (University of British Columbia) |
9:00 am - 9:30 am | Squire Booker (Penn State University)
"Radical mechanisms of post-transcription and post-translational modification"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Chaitan Khosla (Stanford University)
"Polyketide assembly lines: Mechanistic insights and unsolved problems"
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10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Ben Shen (Scripps Florida)
"Discovery of novel enzymes and pathways inspired by natural product biosynthesis"
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11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Wendy Kelly (Georgia Tech)
"Thiostrepton: Engineering new tricks for an old antibiotic"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Emily Balskus (Harvard University)
"Discovery and Characterization of Choline Trimethylamine-Lyase, a New Member of the Glycyl Radical Enzyme Family"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Fundamentals of Enzyme Catalysis |
| Discussion Leader: Peter Tipton (University of Missouri-Columbia) |
7:30 pm - 8:00 pm | Richard Wolfenden (UNC Chapel Hill)
"Benchmarks for transition state affinity and enzyme evolution"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | John Richard (University of Buffalo)
"Triosephosphate isomerase: a paradigm for enzyme-catalyzed proton transfer at carbon"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Karen Allen (Boston University)
"Specificity and promiscuity in a superfamily of phosphatases"
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9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Flavoenzymes |
| Discussion Leader: Audrey Lamb (University of Kansas) |
9:00 am - 9:30 am | Dewey McCafferty (Duke University)
"The flavoenzyme histone demethylase LSD1: Mechanism, biology, and emerging role in breast cancer" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Amnon Kohen (University of Iowa)
"Mechanistic studies of flavin-dependent thymidylate synthase"
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10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Giovanni Gadda (Georgia State University)
"How a single electron and a flavin save lives: the case of nitronate monooxygenase"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Robin Teufel (University Of California San Diego)
"A flavin-N5-oxide as key to an enzymatic Favorskii-type rearrangement"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | David Boehr (Pennsylvania State University)
"Dynamic amino acid networks coordinate catalysis in tryptophan synthase"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Andrew Murkin (University At Buffalo)
"Tapping the active-site water in DXP reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Enzyme Mechanisms and Function |
| Discussion Leader: Peter Bernhardt (Shire HGT) |
7:30 pm - 8:00 pm | Tadhg Begley (Texas A&M University)
"Radical SAM enzymes in cofactor biosynthesis"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Chris Whitman (UT Austin)
"The accidental assignment of function in the tautomerase superfamily"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Lana Saleh (New England Biolabs)
"Biochemical insight into the oxidation of DNA 5-methylcytosine by an iron(II)/a-ketoglutarate-dependent dioxygenase"
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9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemical Biology Tools: Development and Application |
| Discussion Leader: Holly Ellis (Auburn University) |
9:00 am - 9:30 am | Virginia Cornish (Columbia University)
"Expanding the synthetic capabilities of yeast" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Minkui Luo (Memorial Sloan Kettering Cancer Center)
"Expanding biochemical reactivity of S-adenosyl-L-methionine to interrogate methyltransferases"
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10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Pieter Dorrestein (UC San Diego)
"GoogleMAP"-type view of specialized molecules from microbes, their communities and hosts including people"
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11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Anna Mapp (University of Michigan)
"Caught in the act: capturing coactivator assemblies in vitro and in vivo" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Eric Strieter (University of Wisconsin-Madison)
"Understanding the function of atypical ubiquitin modifications"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Amazing Enzymology |
| Discussion Leader: Vahe Bandarian (University of Arizona) |
7:30 pm - 8:20 pm | JoAnne Stubbe (MIT)
"Radicals: your life in their hands"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Chris Walsh (Harvard Medical School)
"Amazing Enzymes: My Personal Hit List"
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9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |