| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Phosphorylation and Disease |
| Discussion Leader: Zhihao Zhuang (University of Delaware) |
| 7:40 pm - 8:10 pm | John Kozarich (ActivX)
"Further ChemoProteomic Adventures in Nucleotide Binding Space"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:50 pm | Dustin Maly (University of Washington, Seattle)
"Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors"
|
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:25 pm | Jin Zhang (Johns Hopkins University)
"Compartmentalized Kinase and Phosphatase Signaling in Living Cells"
|
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Natural Product Biosynthesis |
| Discussion Leader: Minkui Luo (Sloan-Kettering) |
| 9:00 am - 9:30 am | Jon Thorson (University of Kentucky)
"Strategies for Microbial Natural Products Discovery and Chemoenzymatic Diversification"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Helen Blackwell (University of Wisconsin, Madison)
"Synthetic Ligands for the Interception of Bacterial Quorum Sensing Pathways"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Group Photo / Coffee Break |
| 10:50 am - 11:20 am | Hung-Wen (Ben) Liu (University of Texas, Austin)
"Mechanistic Investigations of the Radical SAM Enzyme DesII"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Chris Schofield (University of Oxford)
"The Enzymology of Oxygen Sensing in Humans and Other Organisms"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Joseph Kappock (Purdue)
"Acetic Acid Bacteria Tweak Primary Metabolism to Pass the Acid Test" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Enzymology in Cancer and Cardiovascular Health |
| Discussion Leader: Kay Ahn (Pfizer) |
| 7:30 pm - 8:00 pm | Stefan Gross (Agios)
"Some Specious Object by the Foe Suborn'd: Discovery of Isocitrate Dehydrogenase as the First Cancer Metabolism Gain-of-Function Mutation"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Linda Hsieh-Wilson (Cal Tech)
"Regulation of Cancer Metabolism by O-GlcNAc Glycosylation"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Lynn Abell (Bristol-Myers Squibb)
"Endothelial Lipase: Mechanism Studies and the Search for Reversible Inhibitors"
|
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Chromatin Modifying Enzymes |
| Discussion Leader: Champak Chatterjee (University of Washington) |
| 9:00 am - 9:30 am | Philip Cole (Johns Hopkins University)
"Functions and Mechanisms of Reversible Lysine Modifications"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Robert Copeland (Epizyme)
"Protein Methyltransferase Inhibitors as Personalized Cancer Therapeutics"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Carol Fierke (University of Mich)
"Specificity and Regulation of Metal-Dependent Deacetylases: Implications for Biological Function" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Seongmin Lee (University of Texas, Austin)
"Metal-Dependent Conformational Activation Explains Highly Mutagenic Replication Across O6-Methylguanine by Human DNA Polymerase B" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Xin Zhou (Johns Hopkins University School of Medicine)
"Dynamic Visualization of the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Activity in Living Cells"
|
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Paola Laurino (Weizmann Institute of Science)
"From Engineering the Cofactor of DNA Methylases to the Ancestral Adenosine Cofactor Binding Rossmann Fold"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Nucleic Acid Enzymology |
| Discussion Leader: Emily Weinart (Emory University) |
| 7:30 pm - 8:00 pm | Chuan He (University of Chicago)
"Reversible RNA Methylation in Post-Transcriptional Gene Expression Regulation"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Kenneth Johnson (University of Texas, Austin)
"Role of the Kinetics of Conformational Changes in HIV Reverse Transcriptase Specificity and Evolution of Drug Resistance"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Ronald Raines (University of Wisconsin, Madison)
"Ribonuclease A: From kcat/KM to the Clinic"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Enzyme Mechanisms and Inhibition |
| Discussion Leader: Yan Jessie Zhang (University of Texas, Austin) |
| 9:00 am - 9:30 am | James Wells (UCSF)
"Modulating State-Switching in Caspases Using Antibodies and Small Molecules"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Irene Lee (Case Western Reserve University)
"The Workings of an ATP-Dependent Protease: A Tale of Three Substrates"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Lizbeth Hedstrom (Brandeis University)
"Inhibition and Mechanism in the IMPDH/GMPR Family"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Eranthie Weerapana (Boston College)
"Chemical Proteomic Strategies to Investigate Reactive Cysteines" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Daniel Nomura (Berkeley)
"Mapping Dysregulated Metabolic Pathways in Cancer" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Eileen Jaffe (Fox Chase Cancer Center)
"SAXS and Crystallography Yield New Insights for Mammalian Phenylalanine Hydroxylase"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Mechanisms of Antibiotic Resistance |
| Discussion Leader: Rex Pratt (Wesleyan University) |
| 7:30 pm - 8:00 pm | Gerry Wright (McMaster University)
"The Genomic Enzymology of the Rifamycin Resistome"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Suzanne Walker (Harvard University)
"The Split Personality of O-GlcNAC Transferase"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | John Blanchard (Albert Einstein College of Medicine)
"Acetylation: From Resistance to Regulation"
|
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Metals, Cofactors and Catalysis |
| Discussion Leader: Susan Wang (Washington State University) |
| 9:00 am - 9:30 am | Marty Bollinger (Penn State University)
"Demystifying the Chemical Magic of Non-Heme-Iron Enzymes Involved in Biosynthesis of Bioactive Natural Products"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Amy Rosenzweig (Northwestern University)
"Enzymes and Methane Oxidation"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Raymond Trievel (University of Mich)
"Conservation and Functions of Carbon-Oxygen Hydrogen Bonding in AdoMet-Dependent Methyltransferases"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Tobias Jurgen Erb (ETZ Zurich)
"Fresh Surprises from the Old Cofactor NAD(P)H"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Graham Moran (University of Wisconsin-Milwaukee)
"NAD(P) Aqueous Speciation Reveals a Metabolic Function for Human Renalase"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Frontiers of Enzymology |
| Discussion Leader: Paul Thompson (TSRI) |
| 7:30 pm - 8:20 pm | Don Hilvert (ETH)
"Building Better Enzymes"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:20 pm | Vern Schramm (Albert Einstein College of Medicine)
"On the Nature of Enzymatic Transition States"
|
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
