Find a Conference

Alert - GRC systems are offline for approximately one week. For more information, please click here.

Enzymes, Coenzymes and Metabolic Pathways

Gordon Research Conference

Enzymology: Innovations in Understanding and Impact in Application

July 12 - 17, 2015
Chairs and
Vice Chairs and
Waterville Valley
56 Packard's Road
Waterville Valley, New Hampshire, United States
 Venue and Travel Information

Conference Description

This conference will survey the fundamental and applied aspects of enzymology with a strong emphasis on the impact enzymology can produce at the interface of pharmacology, medicine, and other disciplines. The sessions will cover an array of topics, from innovative techniques to current developments in understanding enzyme mechanisms. Computational approaches, mechanisms of complex systems, and flavoproteins are among the featured topics. As well, the conference will highlight enzymology in drug design and development while providing the enzymologist a high level view of drug discovery. Established and emerging scientists from academic and industrial settings will stimulate discussions and provide perspective on the topics of this conference. The meeting strongly encourages the participation of students and postdoctoral associates and provides opportunities for discussions and networking. There will be opportunities for oral presentations chosen from submitted poster abstracts.

Related Meeting

This GRC will be held in conjunction with the "Enzymes, Coenzymes and Metabolic Pathways" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEnzymology in Drug Development
Session in honor of Dr. Richard N. Armstrong (1948-2015).
Discussion Leader: Robert Copeland (Epizyme, Inc, USA)
7:40 pm - 8:10 pmThomas Meek (Texas A&M University, USA)
"Enzyme Inhibitors that Became Drugs from the 'Rational Design' Approach: Past and Future History"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmMichael Shultz (Novartis, USA)
"Drug-Likeness Defined, Redefined and Undefined"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmErica Pierce (Takeda California, Inc., USA)
"How Target Kinetics Guide Drug Discovery: Implications in Drug Design and In Vivo Pharmacology"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFlavoenzymology
Discussion Leader: Holly Ellis (Auburn University, USA)
9:00 am - 9:30 amBruce Palfey (University of Michigan, USA)
"A New Redox State in Flavin Enzymology"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amPimchai Chaiyen (Mahidol University, Thailand)
"Oxygenation and Beyond by Two-Component Flavin-Dependent Enzymes"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:20 amAnne-Frances Miller (University of Kentucky, USA)
"One Man’s Trash Is an Enzyme’s Substrate: Mechanistic and Structural Features of a Promiscuous Enzyme"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmAndrea Mattevi (University of Pavia, Italy)
"Molecular Recognition in Flavoenzymology"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmNicholas Silvaggi (University of Wisconsin-Milwaukee, USA)
"Unraveling the Biosynthetic Pathway for L-Enduracididine"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmApplications of Metabolic Pathways
Discussion Leader: Fan Fan (Amgen, USA)
7:30 pm - 8:00 pmDavid Cane (Brown University, USA)
"Terpenoid Biosynthesis: The Power of Positive Thinking"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmKenny Wong (Merck Research Labs, USA)
"Altering Cholesterol and Bile Acid Pathways to Treat Metabolic Disease"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmChristopher White (White Labs, USA)
"Why Is Yeast so Critical to Beer Flavor - A Review of Yeast Metabolic Pathways in Beer Fermentation"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmApplications of Enzyme Inhibition
Discussion Leader: Jessica Schneck (GlaxoSmithKline, USA)
9:00 am - 9:30 amRex Pratt (Wesleyan University, USA)
"Beta-Lactamases: Why and How"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amKay Ahn (Janssen Research & Development, USA)
"Discovery and Mechanistic Characterization of Potent and Highly Selective Diacylglycerol Acyltransferase 2 Inhibitors"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amPascal Fortin (Novartis, USA)
"Drugging the Undruggable: Targeting Self-Modulation Mechanisms"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amYimon Aye (Weill Cornell Medical College, USA)
"Conformationally Distinct Hexamers Symbolize a Holistic Mode of Reversible RNR Inhibition"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmAlbert Bowers (University of North Carolina at Chapel Hill, USA)
"Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4+2] Cycloaddition"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAndrew Andrews (Fox Chase Cancer Center, USA)
"Allosteric Regulation of p300 Links DNA Damage and Demethylation to Histone Acetylation and Metabolism"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Circe Effect
Discussion Leader: Anne-Frances Miller (University of Kentucky, USA)
7:30 pm - 8:00 pmCharles Carter (University of North Carolina at Chapel Hill, USA)
"From Urzymes Back Toward the Genetic Code and Forward Toward Allostery"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmPatricia Babbitt (University of California, San Francisco, USA)
"A Large-Scale Perspective on Nature's Strategies for the Evolution of New Catalytic Functions"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDan Herschlag (Stanford University, USA)
"How Enzymes Work"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanisms of Electron Transfer
Discussion Leader: Andrew Murkin (University at Buffalo, State University of New York, USA)
9:00 am - 9:30 amJennifer Dubois (Montana State University, USA)
"The Substrate as Cofactor in Heme Biosynthesis and Degradation"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amVictor Davidson (University of Central Florida, USA)
"Remote Catalysis: Coupling Long Range Electron Transfer to Radical-Mediated Chemistry"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amThomas Poulos (University of California, Irvine, USA)
"The Role of Redox Partner Binding in P450 Proton Coupled Electron Transfer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amFlorian Seebeck (University of Basel, Switzerland)
"Conversion of Iron-Dependent Sulfoxide Synthases onto Thiol Dioxygenases"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmKenichi Yokoyama (Duke University Medical Center, USA)
"Mechanism of Pyranopterin Ring Formation in Molybdenum Cofactor Biosynthesis"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmWenjun Zhang (University of California, Berkeley, USA)
"Microbial Biosynthesis of Terminal Alkenes and Alkynes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNew Analytical Approaches and Applications
Discussion Leader: Kenneth Johnson (University of Texas at Austin, USA)
7:30 pm - 8:00 pmJohn Quinn (Genentech, USA)
"Extending the Capabilities of SPR for Improved Screening and Biophysical Characterization of Enzyme Inhibitors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRommie Amaro (University of California, San Diego, USA)
"Allostery Through the Lens of a Computational Microscope"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmWolf-Dieter Fessner (Technical University of Darmstadt, Germany)
"Systems Biocatalysis - Engineering Artificial Metabolisms In Vitro"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCase Studies in Enzymology
Discussion Leader: Audrey Lamb (University of Kansas, USA)
9:00 am - 9:30 amEllen Moomaw (Kennesaw State University, USA)
"Biochemical Insights into the Manganese Centers of Bicupin Oxalate Oxidase"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amAimin Liu (Georgia State University, USA)
"Mechanistic Enzymology of Tryptophan Kynurenine Pathway"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amEmily Weinert (Emory University, USA)
"Investigating the Mechanism and Role of Globin Coupled Sensor Signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmColin Thorpe (University of Delaware, USA)
"Generating Disulfide Bonds in Metazoans - Enzymology All Tangled up"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMarcello Forconi (College of Charleston, USA)
"Why Would the Tibetan Antelope Eat Detergents? A Story of a Widespread Enzyme and Its (Probably) Unknown Biological Function"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Perspectives on the State of Enzymology and Metabolomics
Discussion Leader: Gregory Reinhart (Texas A&M University, USA)
7:30 pm - 8:20 pmFrank Raushel (Texas A&M University, USA)
"Finding Homes for Orphan Enzymes"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:20 pmStephen Benkovic (Pennsylvania State University, USA)
"Biochemistry in the Cell, the Purinosome"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

Conference Links

Conference History Enzymes, Coenzymes and Metabolic Pathways (GRS)
Additional Fee Info

Bioorganic Chemistry
June 15 - 20, 2025
Enzymes, Coenzymes and Metabolic Pathways (GRS)
July 19 - 20, 2025
Metabolomics and Human Health
February 2 - 7, 2025
Nucleosides, Nucleotides and Oligonucleotides
July 6 - 11, 2025


Contact Us

MyGRC Account
Check your application status, complete your registration, update your poster, change your rooming preference, make a bus reservation, print an invitation letter, print a receipt (which includes verification that you are presenting a poster) or print an invoice by logging into your account.

GRC Venues
Everything you need to know, to plan your trip.

FAQs
Instant answers to common questions.

Tell us how we can help

Call us and leave a detailed message at: 401-783-4011

*This voicemail is only checked once daily. Due to high volume of requests during the conference season, responses may be delayed.

You have no notifications