Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Enzymology in Drug Development |
| Session in honor of Dr. Richard N. Armstrong (1948-2015). |
| Discussion Leader: Robert Copeland (Epizyme, Inc, USA) |
7:40 pm - 8:10 pm | Thomas Meek (Texas A&M University, USA) "Enzyme Inhibitors that Became Drugs from the 'Rational Design' Approach: Past and Future History" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Michael Shultz (Novartis, USA) "Drug-Likeness Defined, Redefined and Undefined" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Erica Pierce (Takeda California, Inc., USA) "How Target Kinetics Guide Drug Discovery: Implications in Drug Design and In Vivo Pharmacology" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Flavoenzymology |
| Discussion Leader: Holly Ellis (Auburn University, USA) |
9:00 am - 9:30 am | Bruce Palfey (University of Michigan, USA) "A New Redox State in Flavin Enzymology" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Pimchai Chaiyen (Mahidol University, Thailand) "Oxygenation and Beyond by Two-Component Flavin-Dependent Enzymes" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Group Photo / Coffee Break |
10:50 am - 11:20 am | Anne-Frances Miller (University of Kentucky, USA) "One Man’s Trash Is an Enzyme’s Substrate: Mechanistic and Structural Features of a Promiscuous Enzyme" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Andrea Mattevi (University of Pavia, Italy) "Molecular Recognition in Flavoenzymology" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Nicholas Silvaggi (University of Wisconsin-Milwaukee, USA) "Unraveling the Biosynthetic Pathway for L-Enduracididine" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Applications of Metabolic Pathways |
| Discussion Leader: Fan Fan (Amgen, USA) |
7:30 pm - 8:00 pm | David Cane (Brown University, USA) "Terpenoid Biosynthesis: The Power of Positive Thinking" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kenny Wong (Merck Research Labs, USA) "Altering Cholesterol and Bile Acid Pathways to Treat Metabolic Disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Christopher White (White Labs, USA) "Why Is Yeast so Critical to Beer Flavor - A Review of Yeast Metabolic Pathways in Beer Fermentation" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Applications of Enzyme Inhibition |
| Discussion Leader: Jessica Schneck (GlaxoSmithKline, USA) |
9:00 am - 9:30 am | Rex Pratt (Wesleyan University, USA) "Beta-Lactamases: Why and How" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Kay Ahn (Janssen Research & Development, USA) "Discovery and Mechanistic Characterization of Potent and Highly Selective Diacylglycerol Acyltransferase 2 Inhibitors" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Pascal Fortin (Novartis, USA) "Drugging the Undruggable: Targeting Self-Modulation Mechanisms" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Yimon Aye (Weill Cornell Medical College, USA) "Conformationally Distinct Hexamers Symbolize a Holistic Mode of Reversible RNR Inhibition" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Albert Bowers (University of North Carolina at Chapel Hill, USA) "Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4+2] Cycloaddition" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Andrew Andrews (Fox Chase Cancer Center, USA) "Allosteric Regulation of p300 Links DNA Damage and Demethylation to Histone Acetylation and Metabolism" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Circe Effect |
| Discussion Leader: Anne-Frances Miller (University of Kentucky, USA) |
7:30 pm - 8:00 pm | Charles Carter (University of North Carolina at Chapel Hill, USA) "From Urzymes Back Toward the Genetic Code and Forward Toward Allostery" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Patricia Babbitt (University of California, San Francisco, USA) "A Large-Scale Perspective on Nature's Strategies for the Evolution of New Catalytic Functions" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Dan Herschlag (Stanford University, USA) "How Enzymes Work" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms of Electron Transfer |
| Discussion Leader: Andrew Murkin (University at Buffalo, State University of New York, USA) |
9:00 am - 9:30 am | Jennifer Dubois (Montana State University, USA) "The Substrate as Cofactor in Heme Biosynthesis and Degradation" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Victor Davidson (University of Central Florida, USA) "Remote Catalysis: Coupling Long Range Electron Transfer to Radical-Mediated Chemistry" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Thomas Poulos (University of California, Irvine, USA) "The Role of Redox Partner Binding in P450 Proton Coupled Electron Transfer" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Florian Seebeck (University of Basel, Switzerland) "Conversion of Iron-Dependent Sulfoxide Synthases onto Thiol Dioxygenases" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Kenichi Yokoyama (Duke University Medical Center, USA) "Mechanism of Pyranopterin Ring Formation in Molybdenum Cofactor Biosynthesis" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Wenjun Zhang (University of California, Berkeley, USA) "Microbial Biosynthesis of Terminal Alkenes and Alkynes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | New Analytical Approaches and Applications |
| Discussion Leader: Kenneth Johnson (University of Texas at Austin, USA) |
7:30 pm - 8:00 pm | John Quinn (Genentech, USA) "Extending the Capabilities of SPR for Improved Screening and Biophysical Characterization of Enzyme Inhibitors" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Rommie Amaro (University of California, San Diego, USA) "Allostery Through the Lens of a Computational Microscope" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Wolf-Dieter Fessner (Technical University of Darmstadt, Germany) "Systems Biocatalysis - Engineering Artificial Metabolisms In Vitro" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Case Studies in Enzymology |
| Discussion Leader: Audrey Lamb (University of Kansas, USA) |
9:00 am - 9:30 am | Ellen Moomaw (Kennesaw State University, USA) "Biochemical Insights into the Manganese Centers of Bicupin Oxalate Oxidase" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Aimin Liu (Georgia State University, USA) "Mechanistic Enzymology of Tryptophan Kynurenine Pathway" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Emily Weinert (Emory University, USA) "Investigating the Mechanism and Role of Globin Coupled Sensor Signaling" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Colin Thorpe (University of Delaware, USA) "Generating Disulfide Bonds in Metazoans - Enzymology All Tangled up" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Marcello Forconi (College of Charleston, USA) "Why Would the Tibetan Antelope Eat Detergents? A Story of a Widespread Enzyme and Its (Probably) Unknown Biological Function" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Perspectives on the State of Enzymology and Metabolomics |
| Discussion Leader: Gregory Reinhart (Texas A&M University, USA) |
7:30 pm - 8:20 pm | Frank Raushel (Texas A&M University, USA) "Finding Homes for Orphan Enzymes" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Stephen Benkovic (Pennsylvania State University, USA) "Biochemistry in the Cell, the Purinosome" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |