| Sunday |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Unusual Natural Product Enzymology |
| Discussion Leader: Squire Booker (Pennsylvania State University, USA) |
| 7:40 pm - 8:10 pm | Bradley Moore (Scripps Institution of Oceanography, USA)
"Marine Natural Products as an Inspiration for New Biosynthetic Enzymology" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Gregory Challis (University of Warwick, United Kingdom)
"Elucidating and Exploiting Biosynthetic C-H Functionalization" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | David Christianson (University of Pennsylvania, USA)
"Structural Biology and Chemistry of Histone Deacetylases in Human Disease and Drug Discovery" |
| 9:20 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Large Complexes |
| Discussion Leader: Martin St. Maurice (Marquette University, USA) |
| 9:00 am - 9:30 am | Timm Maier (University of Basel, Switzerland)
"Structure and Evolution of Fatty Acid and Reducing Polyketide Synthases" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Shelley Minteer (University of Utah, USA)
"Substrate Channeling in Natural and Artificial Krebs Cycle Metabolons" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Group Photo / Coffee Break |
| 10:50 am - 11:05 am | Songon An (University of Maryland, Baltimore County, USA)
"A Regulatory Enzyme Complex for Glucose Metabolism in Living Cells: 'The Glucosome'" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Liang Tong (Columbia University, USA)
"Structure and Function of Large Metabolic Enzymes" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Lorenzo Finci (Tsinghua University, China)
"Structure and Function of the Spliceosome" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Holly Ellis (Auburn University, USA) |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Unusual Coenzymes |
| Discussion Leader: Tadhg Begley (Texas A&M University, USA) |
| 7:30 pm - 8:00 pm | Paul Fitzpatrick (University of Texas Health Science Center, USA)
"Regulation of the Pterin-Dependent Aromatic Amino Acid Hydrolases" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Robert White (Virginia Tech, USA)
"Digging for Metabolic Fossils in the Methanogenic Archaea" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Hung-Wen Liu (University of Texas at Austin, USA)
"Characterization of a Cobalamin-Dependent Radical SAM Enzyme" |
| 9:20 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Enzyme Inhibition |
| Discussion Leader: Lynn Abell (Bristol-Myers Squibb, USA) |
| 9:00 am - 9:30 am | Dennis Murphy (Merck Research Laboratories, USA)
"Determination of In Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Benjamin Cravatt (Scripps Research Institute, USA)
"Enzyme and Inhibitor Discovery Using Chemical Proteomics" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:20 am | Alan Rendina (GlaxoSmithKline, USA)
"A Fatty Acid Synthase KRyptonite for Structure, Mechanism and Cancer" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Brian Miller (Florida State University, USA)
"Allokairic Regulation of Enzyme Function" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Dali Liu (Loyola University Chicago, USA)
"Molecular Recognition of Pyruvate as an Allosteric Activator for ADP-Glucose Pyrophosphorylase from Agrobacterium tumefaciens" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Y. George Zheng (University of Georgia, USA)
"Mechanistic Insights of Protein Arginine Methyltransferases" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metalloenzymes |
| Discussion Leader: Catherine Goodman (Journal of Biological Chemistry, USA) |
| 7:30 pm - 8:00 pm | Pinghua Liu (Boston University, USA)
"Endoperoxide Formation by an a-Ketoglutarate-Dependent Mononuclear Non-Haem Iron Enzyme" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Hideaki Ogata (Max Planck Institute for Chemical Energy Conversion, Germany)
"Catalytic Reaction Mechanism of [NiFe] Hydrogenase" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Amie Boal (Pennsylvania State University, USA)
"Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase" |
| 9:20 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Determining Enzyme Function |
| Discussion Leader: Elham Behshad (Incyte Corp., USA) |
| 9:00 am - 9:30 am | Graham Moran (University of Wisconsin-Milwaukee, USA)
"Renalase, a Decade of Phantoms" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Reuben Peters (Iowa State University, USA)
"Mechanistic Insights from Systematic Investigation of (Di)Terpenoid Biosynthesis" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:05 am | Rebecca Butcher (University of Florida, USA)
"Discovery and Biosynthesis of Hybrid Polyketide-Nonribosomal Peptides in Nematodes" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Valerie De Crecy-Lagard (University of Florida, USA)
"Discovering Novel and Missing Enzymes by Comparative Genomics" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Elizabeth Sattely (Stanford University, USA)
"Plant Pathway Discovery for Plant and Human Health" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Biocatalysis |
| Discussion Leader: Thomas Meek (Texas A&M University, USA) |
| 7:30 pm - 8:00 pm | Jon Stewart (University of Florida, USA)
"Understanding Alkene Reductases and Learning How to Make Them Better Biocatalysts" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Robert Dicosimo (DuPont Industrial Biosciences, USA)
"Enzymatic Production of Soluble Carbohydrate Fiber for Food Ingredient Applications" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Kevin Walker (Michigan State University, USA)
"Biocatalysis and Repurposing of Enzymes on Pathways to Bioactive Natural Products" |
| 9:20 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Assembly Lines |
| Discussion Leader: Barbara Gerratana (National Institute of General Medical Sciences, NIH, USA) |
| 9:00 am - 9:30 am | Sheryl Tsai (University of California, Irvine, USA)
"Structural Enzymology and Protein Dynamics of Fatty Acid, Polyketide, and Nonribosomal Peptide Megasynthases" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Steven Bruner (University of Florida, USA)
"Structure and Mechanism of the Transporter for the E. coli Genotoxin, Colibactin" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Charles Melancon (University of New Mexico, USA)
"A Bioinformatic Roadmap for Discovering and Engineering Type II Polyketide Biosynthetic Pathways and Enzymes" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:20 am | Jorn Piel (Institute of Microbiology, ETH Zurich, Switzerland)
"Investigating and Utilizing trans-AT Polyketide Synthase Assembly Lines" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Andrew Gulick (Hauptman-Woodward Medical Research Institute, University at Buffalo, USA)
"Conformational Changes that Drive the Dynamic Structural Cycle of the Nonribosomal Peptide Synthetases" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Martin Schmeing (McGill University, Canada)
"Visualizing the First Steps of a Megaenzyme Making an Antibiotic" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Keynote Session: Learning from Naturally Gifted Enzymes |
| Discussion Leader: Karen Allen (Boston University, USA) |
| 5:30 pm - 6:20 pm | Debra Dunaway-Mariano (University of New Mexico, USA)
"Catalytic Diversity Among Phosphotransferases: Vignettes of Mechanism and Molecular Evolution" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 7:20 pm | Dale Poulter (University of Utah, USA)
"Biosynthesis of Squalene. Five Enzymes, Two Coenzymes, and a Metabolic Pathway" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
