Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Novel Cofactors and Chemistry
7:40 pm - 8:10 pm
"Prenyl-Flavin: A New Cofactor for Aromatic Decarboxylations"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Lactate Racemase and Its Novel Ni-Pincer Cofactor"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Discovery of a PLP-Dependent Oxidase in the Pathway to the Antibiotic Indolmycin"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Structural Methodology
9:00 am - 9:30 am
"High-Resolution Protein Structures by CryoEM - Is Crystallography Obsolete"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Atomic Resolution Cryo-EM of Metabolic Enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
"Structure and Dynamics from Single-Particle Snapshots"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"MauG Catalysis: A Tale of Ferryl Iron, Radicals and Long Distance Hopping"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Metabolite Repair, a Neglected but Essential Aspect of Intermediary Metabolism: The Case for Nit1 in the Recycling of Damaged Glutathione"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"On the Mechanism of Generation, Recognition, and Erasure of DNA Modifications"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"New Metallo-Enzymes Regulating Protein Biosynthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Role of Catalysis in Mitotic Checkpoint Control over the Cell Cycle"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enzyme Discovery, Structure and Mechanism
9:00 am - 9:30 am
"Investigations of Regulatory and Functional Diversity in an Enzyme Superfamily"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Regulation of Carrier Domain Movements in Pyruvate Carboxylase"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Noncanonical Reactions Catalyzed by Atypical Flavoenzymes"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"A Simplified Approach for the Determination of the Bi-Bi Steady-State Kinetic Mechanism of PA0660"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Old and New Twists on Cytochrome P450: Desaturation, C-C Bond Cleavage, and Reversible Oxidation of the Thiolate Heme Ligand"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Directed Evolution of Abiological Catalysts Based on Heme Proteins"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"H Transfer and Biocatalysis with Natural and Artificial Coenzymes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Using Chemoproteomic Platforms to Map Druggable Hotspots in Human Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Probing the Cofactor Biogenesis in Cysteine Dioxygenase with Unnatural Amino Acid"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Chemical Approaches to Investigate Protein Glutathionylation in Stress"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Alpha-Synuclein Sensitizes Transglutaminase 2 (TG2) to Ca2+ Activation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Regio-Complementary Carboxylation of Aromatics: Diverging Reactivities Through Different Enzyme Mechanisms"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Treatment of Inborn Errors of Metabolism by Small Molecule Allosteric Activators"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Development of New and Improved Enzymes for Industrial Biocatalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Protein Dynamics and Catalysis: Evolution and Artificial Design"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mechanisms of Mononuclear Non-Heme Enzymes Studied with Computational Methods"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Recreating the Evolution of Enzyme Catalysis Over 3.5 Billion Years"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Investigating Glycopeptide Antibiotic Biosynthesis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Method to Access Novel Allosteric Regulators and What They Can Teach Us"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Biosynthesis of Non-Proteinogenic Amino Acids"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The Evolving State of the Art
5:30 pm - 6:20 pm
"How Can One Enzyme Act on 30 Different Substrates?"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 7:20 pm
"A Century of Enzyme Kinetic Analysis"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
