Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Regulation of Protein Function
Discussion Leader: Bo Li (University of North Carolina at Chapel Hill, USA)
7:40 pm - 8:10 pm
Hening Lin (Howard Hughes Medical Institute / Cornell University, USA)
"Novel Post-Translational Modifications that Regulates Cell Signaling Proteins in Cancer"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Joan Hevel (Utah State University, USA)
"Redox Regulation of Protein Arginine Methyltransferase 1 (PRMT1)"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Natalie Ahn (University of Colorado Boulder, USA)
"MAP Kinase Regulation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanistic Features of Enzyme Cofactors
Discussion Leader: Bruce Palfey (University of Michigan, USA)
9:00 am - 9:30 am
Michael Marletta (University of California, Berkeley, USA)
"Polysaccharide Monooxygenases: Structure and Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Dennis Stuehr (Cleveland Clinic, USA)
"Unraveling the Mechanisms of Heme Transport and Insertion into Hemeproteins"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
Douglas Goodwin (Auburn University, USA)
"Intramolecular Electron Transfer for Self-Preservation and Bifunctional Catalysis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Michael McLeish (Indiana University - Purdue University Indianapolis, USA)
"Thiamin Diphosphate… Don't We Already Know Everything About That?"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Elizabeth Trimmer (Grinnell College, USA)
"Exploring a Proton Relay Mechanism in the Folate Half-Reaction of E. coli Methylenetetrahydrofolate Reductase"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Audrey Lamb (University of Kansas, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Natural Product Biosynthesis
Discussion Leader: Adrian Keatinge-Clay (University of Texas at Austin, USA)
7:30 pm - 8:00 pm
Satish Nair (University of Illinois at Urbana-Champaign, USA)
"Biosynthesis of the Antibiotic Core of a Large Class of Protein Synthesis Inhibitors"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Gavin Williams (North Carolina State University, USA)
"Engineering the Biosynthesis of Unnatural Polyketides and Isoprenoids"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Vahe Bandarian (University of Utah, USA)
"Discovery and Characterization of Radical Enzymatic Transformations in Natural Product Biosynthetic Pathways"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enzyme Inhibition
Discussion Leader: Randy Kipp (Relay Therapeutics, USA)
9:00 am - 9:30 am
Craig Crews (Yale University, USA)
"PROTAC-Mediated Protein Degradation: The Chemical Equivalent of RNAi"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Daniel Krosky (Janssen R&D, USA)
"Leveraging Biochemical Assays to Discover and Characterize Inhibitors of Nucleic Acid-Processing Enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
R. Kip Guy (University of Kentucky, USA)
"Regulating Cullin Function by Controlling Neddylation Through Targeting DCN1"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Jeremy Lohman (Purdue University, USA)
"Malonyl-Thioester Isosteres as Probes of Enzyme Structure-Function Relationships"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Claire Stines-Chaumeil (Centre de Recherche Paul Pascal (UMR 5031), France)
"Kinetic Mechanism of a New Multicopper Oxidase: The Bilirubin Oxidase from Bacillus pumilus "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Anirban Banerjee (National Institutes of Health, USA)
"Molecular Mechanism of Protein Palmitoylation Catalyzed by the DHHC Family of Integral Membrane Enzymes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Methods
Discussion Leader: Susan Miller (University of California, San Francisco, USA)
7:30 pm - 8:00 pm
Barry Honig (Columbia University, USA)
"Structure-Based Prediction of Protein-Protein and Protein-Ligand Interactions on a Genomic Scale"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Richard Friesner (Columbia University, USA)
"Computational Methods for Modeling Protein Active Site Chemistry: What Are the Key Challenges to Achieving Chemically Accurate Predictions, and How Can They Be Effectively Addressed?"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Neil Kelleher (Northwestern University, USA)
"Native Proteomics: Wholistic Characterization of Endogenous Protein Complexes from Human Cells"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enzyme Mechanisms
Discussion Leader: Keri Colabroy (Muhlenberg College, USA)
9:00 am - 9:30 am
Brian Miller (Florida State University, USA)
"Dynamic Regulation of Enzyme Action In Vitro and In Vivo "
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Erika Taylor (Wesleyan University, USA)
"When Enzymology Meets Biophysics in a GT-B Glycosyltransferase"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Donald Becker (University of Nebraska-Lincoln, USA)
"Redox-Mediated Allosteric Regulation of Proline Utilization A"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Andrew Murkin (University at Buffalo, USA)
"Inhibition of Mycobacterium tuberculosis Isocitrate Lyase Using Masked Electrophiles"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Katherine Hicks (SUNY Cortland, USA)
"Structural and Functional Characterization of NicC, a Decarboxylative Hydroxylase"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Drug Discovery
Discussion Leader: Jessica Ward (Pfizer, USA)
7:30 pm - 8:00 pm
Mario van der Stelt (Leiden University, The Netherlands)
"Profiling the Protein-Ligand Interaction Landscape by Chemical Proteomics to Guide Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Adam Johnson (Genentech, USA)
"Discovery of Bruton's Tyrosine Kinase Inhibitors"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Richard Miller (Merck, USA)
"Discovery of Mechanistically Diverse Protein Kinase Inhibitors"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Pathways and Metabolomics
Discussion Leader: Daniel Bachovchin (Memorial Sloan-Kettering Cancer Center, USA)
9:00 am - 9:30 am
Alexandre Zanghellini (Arzeda Corporation, USA)
"From Bits to Molecules: Computational Design of Novel Enzymatic Pathways"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Zhihao Zhuang (University of Delaware, USA)
"Investigating Protein Deubiquitination Using Activity-Based Probes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Michael Fischbach (Stanford University, USA)
"Small Molecules from the Human Microbiota"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Emily Weinert (Emory University, USA)
"Probing the Metabolism and Cellular Roles of 2',3'-Cyclic Nucleotide Monophosphates"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Sanjay Hari (Massachusetts Institute of Technology, USA)
"Structure and Regulation of E. coli Cyclopropane Fatty Acid Synthase"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Rajesh Nagarajan (Boise State University, USA)
"Beta-Ketoacyl-ACP Substrate Mimics for 3-Oxoacyl-ACP Utilizing AHL Synthases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Structural Basis for Enzyme Mechanisms
Discussion Leader: John Gerlt (University of Illinois at Urbana-Champaign, USA)
5:30 pm - 6:20 pm
Karen Allen (Boston University, USA)
"Form Follows Function: Evolution of Protein Scaffolds for Phosphoryl Group Transfer"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 7:20 pm
Dagmar Ringe (Brandeis University, USA)
"One Protein, Two Enzymes"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
