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Enzymes, Coenzymes and Metabolic Pathways

Gordon Research Conference

Advances in Enzymology: From Mechanism and Function to Therapeutic Applications

July 22 - 27, 2018

Chairs

and

Vice Chairs

and

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The 2018 Gordon Research Conference on Enzymes, Coenzymes and Metabolic Pathways will highlight a broad range of topics from mechanism and function to therapeutic applications in enzymology. Speakers participating at this conference will include both established and emerging leaders from academia and industry to promote diverse perspectives and inspire stimulating productive discussions among attendees. Additional speakers will be selected from submitted poster abstracts. The conference strongly encourages the participation of graduate students and postdoctoral fellows, providing a platform for dialog and networking with experts in the field. This conference will afford scientists from various research areas the opportunity to explore new ideas and approaches in enzymology through stimulating scientific exchange.

Related Meeting

This GRC will be held in conjunction with the "Enzymes, Coenzymes and Metabolic Pathways" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Regulation of Protein Function Discussion Leader:
7:40 pm - 8:10 pm	"Novel Post-Translational Modifications that Regulates Cell Signaling Proteins in Cancer"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:45 pm	"Redox Regulation of Protein Arginine Methyltransferase 1 (PRMT1)"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"MAP Kinase Regulation"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Mechanistic Features of Enzyme Cofactors Discussion Leader:
9:00 am - 9:30 am	"Polysaccharide Monooxygenases: Structure and Function"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Unraveling the Mechanisms of Heme Transport and Insertion into Hemeproteins"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Group Photo / Coffee Break
10:50 am - 11:20 am	"Intramolecular Electron Transfer for Self-Preservation and Bifunctional Catalysis"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	"Thiamin Diphosphate… Don't We Already Know Everything About That?"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Exploring a Proton Relay Mechanism in the Folate Half-Reaction of E. coli Methylenetetrahydrofolate Reductase"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Natural Product Biosynthesis Discussion Leader:
7:30 pm - 8:00 pm	"Biosynthesis of the Antibiotic Core of a Large Class of Protein Synthesis Inhibitors"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Engineering the Biosynthesis of Unnatural Polyketides and Isoprenoids"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Discovery and Characterization of Radical Enzymatic Transformations in Natural Product Biosynthetic Pathways"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Enzyme Inhibition Discussion Leader:
9:00 am - 9:30 am	"PROTAC-Mediated Protein Degradation: The Chemical Equivalent of RNAi"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Leveraging Biochemical Assays to Discover and Characterize Inhibitors of Nucleic Acid-Processing Enzymes"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Regulating Cullin Function by Controlling Neddylation Through Targeting DCN1"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Malonyl-Thioester Isosteres as Probes of Enzyme Structure-Function Relationships"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Kinetic Mechanism of a New Multicopper Oxidase: The Bilirubin Oxidase from Bacillus pumilus"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Molecular Mechanism of Protein Palmitoylation Catalyzed by the DHHC Family of Integral Membrane Enzymes"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Emerging Methods Discussion Leader:
7:30 pm - 8:00 pm	"Structure-Based Prediction of Protein-Protein and Protein-Ligand Interactions on a Genomic Scale"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Computational Methods for Modeling Protein Active Site Chemistry: What Are the Key Challenges to Achieving Chemically Accurate Predictions, and How Can They Be Effectively Addressed?"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Native Proteomics: Wholistic Characterization of Endogenous Protein Complexes from Human Cells"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Enzyme Mechanisms Discussion Leader:
9:00 am - 9:30 am	"Dynamic Regulation of Enzyme Action In Vitro and In Vivo"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"When Enzymology Meets Biophysics in a GT-B Glycosyltransferase"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Redox-Mediated Allosteric Regulation of Proline Utilization A"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	"Inhibition of Mycobacterium tuberculosis Isocitrate Lyase Using Masked Electrophiles"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Structural and Functional Characterization of NicC, a Decarboxylative Hydroxylase"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Drug Discovery Discussion Leader:
7:30 pm - 8:00 pm	"Profiling the Protein-Ligand Interaction Landscape by Chemical Proteomics to Guide Drug Discovery"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Discovery of Bruton's Tyrosine Kinase Inhibitors"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Discovery of Mechanistically Diverse Protein Kinase Inhibitors"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Metabolic Pathways and Metabolomics Discussion Leader:
9:00 am - 9:30 am	"From Bits to Molecules: Computational Design of Novel Enzymatic Pathways"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Investigating Protein Deubiquitination Using Activity-Based Probes"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Small Molecules from the Human Microbiota"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Probing the Metabolism and Cellular Roles of 2',3'-Cyclic Nucleotide Monophosphates"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Structure and Regulation of E. coli Cyclopropane Fatty Acid Synthase"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Beta-Ketoacyl-ACP Substrate Mimics for 3-Oxoacyl-ACP Utilizing AHL Synthases"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Structural Basis for Enzyme Mechanisms Discussion Leader:
5:30 pm - 6:20 pm	"Form Follows Function: Evolution of Protein Scaffolds for Phosphoryl Group Transfer"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 7:20 pm	"One Protein, Two Enzymes"
7:20 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Elsevier - Archives of Biochemistry and Biophysics

Conference Links

Conference History Enzymes, Coenzymes and Metabolic Pathways (GRS)

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