Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Origins of Biocatalysis
The program begins with a discussion of how biocatalysis arose in prebiotic times and in the earliest forms of life.
7:40 pm - 8:10 pm
"From Minerals to Metalloproteins: Probing Primitive Pathways of Iron Sulfur Cluster Biosynthesis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"'Ox in Hox' and 'The Best Nest': Exploring the Evolutionary History of Nitrogenases and Hydrogenases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"RNA and Protein: A Match Made in the Hadean"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Convergent Allostery in Ribonucleotide Reductase"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mechanism and Evolution of Assembly Line Polyketide Synthases"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
"Ex Vivo Metabolism: Novel Enzyme Cascades to Synthesize Active Pharmaceutical Ingredients"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Multi-Step Substrate Processing and Coordinated Conformational Changes by the Proteasome Molecular Machine"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Enzymatic Spiroketal Formation via Oxidative Rearrangement and Distortion of a Polycyclic Polyketide Backbone"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymes and Metabolic Pathways in Biotechnology
7:30 pm - 8:00 pm
"Reconstructing Proteins to Understand Their Evolution and Diversity in Specialized Metabolic Pathways"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Metalloprotein Catalysts as Agricultural Biotechnology Tools"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Designed Allosteric Regulation of Metabolic Pathways and What We Can Do with It"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Pathway Evolution and Engineering
9:00 am - 9:30 am
"Enzymes for Lignin and Plastics Conversion"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Insights from Systematic Analysis of Diterpenoid Metabolism"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Metabolic Alteration Is EASy: A Novel Method for Rapid Evolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Shifting Roles of Functionally Important Amino Acids During Evolution Contributes to the Difficulty of Explaining Enzyme Specificity"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Primordial-Like Enzymes from Bacteria with Reduced Genomes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"1,2,4-Triazine Natural Products. Genome Mining and Biochemical Discovery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymes and Metabolic Pathways in Human Disease
7:30 pm - 8:00 pm
"cGAS-Mediated Biocatalytic Synthesis of Complex Cyclic Dinucleotide STING Agonists Enables Rapid SAR Exploration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Selectivity of Lysine Acetyltransferases"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"New Insights into Heme Metabolism in Malaria Parasites"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Druggable Enzyme Mechanisms and Inhibition
9:00 am - 9:30 am
"Unraveling the Biosynthesis of the Anti-Cancer Agent Azinomycin B"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Discovery of a Cryptic Peptide Binding Site on PCSK9 and Design of Antagonists"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Inhibition of Biotin Synthase by Acidomycin Reveals Unusual Kinetic Complexity and Suggests a Highly Effective Antimycobacterial Target"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Structural Insight into Large Domain Movements and Cofactor Specificity of Bacterial HMG-CoA Reductase"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"The Role of Catalysis and Environmental Regulation in IDH1-Driven Cancers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Tunable Chemistry for Global Discovery of Protein Function and Ligands"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Enzyme Design and Evolution
7:30 pm - 8:00 pm
"Promiscuity, Serendipity and Metabolic Innovation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Interactive Simulation of Enzyme Dynamics and Mechanisms for Design, Optimization and Evolution"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Enzyme Discovery, Engineering and Applications in Biocatalysis: Case Studies for Transaminases, Plastic-Degrading Enzymes and the Degradation of Complex Marine Carbohydrates"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fundamentals of Catalysis
9:00 am - 9:30 am
"Electric Fields: Enzyme Catalysis and Evolution"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Conformational Dynamics and the Evolution of New Enzyme Functions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Protein Structure and Dynamics Using X-Ray Free-Electron Lasers"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Multiscale Modeling of Complex Enzyme Reactions: From Free Energy Simulations to Consensus Docking"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Closer to the Madding Crowd: Probing Enzyme Catalysis in Cell-Like Environs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: The Future of Enzyme Science
5:30 pm - 6:20 pm
"Combining Cryo-EM with Crystallography to Capture Snapshots of Metalloenzymes in Action"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 7:20 pm
"Radical SAM Enzymes: A Past, Present and Future Full of Surprises"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure