Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Origins of Biocatalysis
The program begins with a discussion of how biocatalysis arose in prebiotic times and in the earliest forms of life.
Discussion Leader: Wayne Patrick (Victoria University of Wellington, New Zealand)
7:40 pm - 8:10 pm
Eric Boyd (Montana State University, USA)
"From Minerals to Metalloproteins: Probing Primitive Pathways of Iron Sulfur Cluster Biosynthesis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
John Peters (Washington State University, USA)
"'Ox in Hox' and 'The Best Nest': Exploring the Evolutionary History of Nitrogenases and Hydrogenases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Loren Williams (Georgia Institute of Technology, USA)
"RNA and Protein: A Match Made in the Hadean"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Large Enzyme Complexes
Discussion Leader: Tonya Zeczycki (Brody School of Medicine, East Carolina University, USA)
9:00 am - 9:30 am
Nozomi Ando (Cornell University, USA)
"Convergent Allostery in Ribonucleotide Reductase"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Chaitan Khosla (Stanford University, USA)
"Mechanism and Evolution of Assembly Line Polyketide Synthases"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
Grant Murphy (Merck & Co., USA)
"Ex Vivo Metabolism: Novel Enzyme Cascades to Synthesize Active Pharmaceutical Ingredients"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Andreas Martin (Howard Hughes Medical Institute / University of California, Berkeley, USA)
"Multi-Step Substrate Processing and Coordinated Conformational Changes by the Proteasome Molecular Machine"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Robin Teufel (University of Freiburg, Germany)
"Enzymatic Spiroketal Formation via Oxidative Rearrangement and Distortion of a Polycyclic Polyketide Backbone"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Jennifer DuBois (Montana State University, USA) and Matthew Gentry (University of Kentucky, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymes and Metabolic Pathways in Biotechnology
Discussion Leader: Andrew Gulick (University at Buffalo, USA)
7:30 pm - 8:00 pm
Dinesh Christendat (University of Toronto, Canada)
"Reconstructing Proteins to Understand Their Evolution and Diversity in Specialized Metabolic Pathways"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Robert Cicchillo (Corteva Agriscience™, USA)
"Metalloprotein Catalysts as Agricultural Biotechnology Tools"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Luiz Pedro Carvalho (The Francis Crick Institute, United Kingdom)
"Designed Allosteric Regulation of Metabolic Pathways and What We Can Do with It"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Pathway Evolution and Engineering
Discussion Leader: Lawrence Wackett (University of Minnesota, USA)
9:00 am - 9:30 am
Gregg Beckham (National Renewable Energy Laboratory, USA)
"Enzymes for Lignin and Plastics Conversion"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Reuben Peters (Iowa State University, USA)
"Insights from Systematic Analysis of Diterpenoid Metabolism"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Ellen Neidle (University of Georgia, USA)
"Metabolic Alteration Is EASy: A Novel Method for Rapid Evolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Margaret Glasner (Texas A&M University, USA)
"Shifting Roles of Functionally Important Amino Acids During Evolution Contributes to the Difficulty of Explaining Enzyme Specificity"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Wayne Patrick (Victoria University of Wellington, New Zealand)
"Primordial-Like Enzymes from Bacteria with Reduced Genomes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Benjamin Philmus (Oregon State University, USA)
"1,2,4-Triazine Natural Products. Genome Mining and Biochemical Discovery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymes and Metabolic Pathways in Human Disease
Discussion Leader: Matthew Gentry (University of Kentucky, USA)
7:30 pm - 8:00 pm
Brian Andresen (Merck, USA)
"cGAS-Mediated Biocatalytic Synthesis of Complex Cyclic Dinucleotide STING Agonists Enables Rapid SAR Exploration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Andrew Andrews (Fox Chase Cancer Center, USA)
"Selectivity of Lysine Acetyltransferases"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Jacquin Niles (Massachusetts Institute of Technology, USA)
"New Insights into Heme Metabolism in Malaria Parasites"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Druggable Enzyme Mechanisms and Inhibition
Discussion Leader: Stuart Licht (Moderna Therapeutics, USA)
9:00 am - 9:30 am
Coran Watanabe (Texas A&M University, USA)
"Unraveling the Biosynthesis of the Anti-Cancer Agent Azinomycin B"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Daniel Kirchhofer (Genentech, Inc., USA)
"Discovery of a Cryptic Peptide Binding Site on PCSK9 and Design of Antagonists"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Joseph Jarrett (University of Hawaii at Manoa, USA)
"Inhibition of Biotin Synthase by Acidomycin Reveals Unusual Kinetic Complexity and Suggests a Highly Effective Antimycobacterial Target"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Yan Kung (Bryn Mawr College, USA)
"Structural Insight into Large Domain Movements and Cofactor Specificity of Bacterial HMG-CoA Reductase"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Christal Sohl (San Diego State Univerisity, USA)
"The Role of Catalysis and Environmental Regulation in IDH1-Driven Cancers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Ku-Lung Hsu (University of Virginia, USA)
"Tunable Chemistry for Global Discovery of Protein Function and Ligands"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Enzyme Design and Evolution
Discussion Leader: Lisa Olshansky (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 8:00 pm
Shelley Copley (University of Colorado Boulder, USA)
"Promiscuity, Serendipity and Metabolic Innovation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Adrian Mulholland (University of Bristol, United Kingdom)
"Interactive Simulation of Enzyme Dynamics and Mechanisms for Design, Optimization and Evolution"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Uwe Bornscheuer (University of Greifswald, Germany)
"Enzyme Discovery, Engineering and Applications in Biocatalysis: Case Studies for Transaminases, Plastic-Degrading Enzymes and the Degradation of Complex Marine Carbohydrates"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fundamentals of Catalysis
Discussion Leader: Steven Schwartz (University of Arizona, USA)
9:00 am - 9:30 am
Steven Boxer (Stanford University, USA)
"Electric Fields: Enzyme Catalysis and Evolution"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Lynn Kamerlin (Uppsala University, Sweden)
"Conformational Dynamics and the Evolution of New Enzyme Functions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Ilme Schlichting (Max Planck Institute for Medical Research, Germany)
"Protein Structure and Dynamics Using X-Ray Free-Electron Lasers"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Dan Major (Bar-Ilan University, Israel)
"Multiscale Modeling of Complex Enzyme Reactions: From Free Energy Simulations to Consensus Docking"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Natalia Yewdall (Institute for Complex Molecular Systems, Eindhoven University of Technology, The Netherlands)
"Closer to the Madding Crowd: Probing Enzyme Catalysis in Cell-Like Environs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: The Future of Enzyme Science
Discussion Leader: Graham Moran (Loyola University Chicago, USA)
5:30 pm - 6:20 pm
Catherine Drennan (Massachusetts Institute of Technology, USA)
"Combining Cryo-EM with Crystallography to Capture Snapshots of Metalloenzymes in Action"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 7:20 pm
Joan Broderick (Montana State University, USA)
"Radical SAM Enzymes: A Past, Present and Future Full of Surprises"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure