Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Enzyme Function and Mechanism
Discussion Leader: Vinayak Agarwal (Georgia Institute of Technology, United States)
7:40 pm - 8:10 pm
Karen Allen (Boston University, United States)
"Leveraging Sequence and Structure to Unravel Specificity in Glycoconjugate Biosynthesis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Wen Shan Yew (National University of Singapore, Singapore)
"Repurposing Biology through Synthetic Enzymology for Human and Planetary Health"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Wilfred van der Donk (HHMI and the University of Illinois at Urbana-Champaign, United States)
"Genome Mining for New Enzymatic Activity"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enzymology of Complex Systems
Discussion Leader: Y. Jessie Zhang (University of Texas, Austin, United States)
9:00 am - 9:30 am
Matthias Wilmanns (EMBL, Germany)
"Tracking Catalysis by High-Resolution Structural Movies in Product/Substrate Tunnel-Containing Multi Enzyme Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Heather Hundley (Indiana University, United States)
"Mechanisms of in vivo Target Recognition by the ADAR family of RNA Modification Enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 11:15 am
Ramaswamy Subramanian (Purdue University, United States)
"The Two Different Active Sites in Trimethyl N-Oxide Demethylase"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
Rafael Guimaraes da Silva (University of St Andrews, United Kingdom)
"Allostery, Dynamics, and Catalysis in Short-Form ATP Phosphoribosyltransferase"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yang Yang (University of California Santa Barbara, United States)
"New Strategies for Stereoselective Unnnatural Radical Biocatalysis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Quinlin Hanson (NIH/NCATS, United States)
"Target Class Profiling of Small Molecule Methyltransferases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Erika Taylor (Wesleyan University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biocatalysis and Synthetic Biology
Discussion Leader: Ghader Bashiri (The University of Auckland, New Zealand)
7:30 pm - 8:00 pm
Yifan Wang (University of Georgia, United States)
"Defining the Function of a Heme Enzyme in Rufomycin Biosynthesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
John McIntosh (Merck & Co., United States)
"An Engineered Proline Hydroxylase Enables Concise Synthesis of Belzutifan"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Todd Hyster (Princeton University, United States)
"Photoenzymatic Catalysis - Using Light to Reveal New Enzyme Functions"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Anti-Infective Biosynthesis
Discussion Leader: Hua Wang (University of Glasgow, United Kingdom)
9:00 am - 9:30 am
Jaclyn Winter (University of Utah, United States)
"Harnessing the Chemical Potential of Unprecedented Microbes from Great Salt Lake for Antibiotic Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Jesko Koehnke (Leibniz Universität Hannover , Germany)
"Crocagins - A Curious Case of Peptide-Derived Pyrroloindoline Alkaloids"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
David Christianson (University of Pennsylvania, United States)
"Structural Insight on Assembly-Line Catalysis in Terpene Biosynthesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
Ikuro Abe (The University of Tokyo, Japan)
"Unusual Enzyme Reactions in Natural Product Biosynthesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Elizabeth Parkinson (Purdue University, United States)
"Synthetic Natural Product Inspired Cyclic Peptides for Discovery of Bioactive Natural Products and Biocatalysts"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Wen Zhu (Florida State University, United States)
"Mapping Protein-Protein Interactions in a Multi-Component Radical SAM Enzyme"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metals in Biochemistry
Discussion Leader: Jennifer Bridwell-Rabb (University of Michigan, United States)
7:30 pm - 8:00 pm
N. Cecilia Martinez-Gomez (University of California, Berkeley, United States)
"Unraveling the Role of Lanthanides in the [Ecosystem] and the Metabolism of its Microbial Occupants"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Akif Tezcan (University of California, San Diego, United States)
"Mechanism of Energy Transduction in Biological Nitrogen Fixation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Bo Li (University of North Carolina at Chapel Hill, United States)
"Unconventional Iron-Dependent Enzymes in Antibiotic Biosynthesis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Principles of Enzyme Catalysis
Discussion Leader: James Errey (Evotec, United Kingdom)
9:00 am - 9:30 am
Clarissa Czekster (University of St Andrews, United Kingdom)
"Enzymology of Metalloaminopeptidases from Pseudomonas Aeruginosa "
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Randy Kipp (Relay Therapeutics, United States)
"Targeting Selective Conformational Dynamics for Enzyme Inhibition"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Doug Mitchell (Univ. of Illinois at Urbana-Champaign, United States)
"RiPP Therapy for Building a Better Backbone"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Brandon Greene (University of California, Santa Barbara, United States)
"Understanding and Exploiting Thiyl Radical Cofactors."
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Katherine O'Toole (New England Biolabs, United States)
"Surveying the Diversity of 5-Methylpyrimidine Dioxygenases and their Role in Base Modification"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Rebecca Switzer (Bucknell University, United States)
"ADCA-DN-Linked Mutations Relieve Normal Autoinhibition in DNA Methyltransferase"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Claire Stines-Chaumeil (Centre de Recherche Paul Pascal (UMR 5031), France)
"Artificial Bifunctional Enzymes: Antimicrobial Topological and Enzymatic Properties"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzyme Function and Engineering
Discussion Leader: Andrea Mattevi (University of Pavia, Italy)
7:30 pm - 8:00 pm
Joelle Pelletier (Université de Montréal, Canada)
"The Little Protein that Could: Evolution of a Powerful Antibiotic Resistance Enzyme"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Michelle Chang (University of California, Berkeley, United States)
"Discovery and Applications of Halogenase Chemistry"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Marcus Hartmann (Max Planck Society, Germany)
"Enzyme Fusions in Metabolic Pathways"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Emerging New Methods in Enzymology
Discussion Leader: Michelle Bond (NIGMS/NIH, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Margaux Pinney (University of California, San Francisco, United States)
"From Atoms to Evolution and Disease: Leveraging Microfluidics to Dissect Enzymes in High-Throughput"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Lynn Kamerlin (Georgia Institute of Technology, United States)
"Modulating Loop Dynamics and the Evolution of New Enzymes"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Mohammad Seyedsayamdost (Princeton University, United States)
"Discovering and Engineering New Metalloenzymes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Marco Bellinzoni (Institut Pasteur, France)
"Actinobacteria do it Differently: Surprising Features of a Mixed PDH/ODH Metabolic Supercomplex"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Myles Poulin (University of Maryland at College Park, United States)
"Chemical and Biochemical Tools to Examine the Role of Exopolysaccharides in Bacterial Biofilm Formation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Elizabeth Skellam (University of North Texas, United States)
"Investigating and Adapting Oxidative Transformations during Cytochalasan Biosynthesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kou-San Ju (The Ohio State University, United States)
"Biosynthetic Diversification of the Phosphonoalamide Natural Product Family"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Biocatalysis and Enzymology for Translational Biochemistry
Discussion Leader: Andrew Gulick (University at Buffalo, SUNY, United States)
7:30 pm - 8:15 pm
Chaitan Khosla (Stanford University, United States)
"Mechanistic Principles of Assembly-Line Polyketide Biosynthesis"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Ruma Banerjee (University of Michigan, United States)
"Enzymes and Coenzymes in the Sulfur Metabolic Pathway"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure