Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Enzyme Function and Mechanism
7:40 pm - 8:10 pm
"Leveraging Sequence and Structure to Unravel Specificity in Glycoconjugate Biosynthesis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Repurposing Biology through Synthetic Enzymology for Human and Planetary Health"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Genome Mining for New Enzymatic Activity"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enzymology of Complex Systems
9:00 am - 9:30 am
"Tracking Catalysis by High-Resolution Structural Movies in Product/Substrate Tunnel-Containing Multi Enzyme Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mechanisms of in vivo Target Recognition by the ADAR family of RNA Modification Enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 11:15 am
"The Two Different Active Sites in Trimethyl N-Oxide Demethylase"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Allostery, Dynamics, and Catalysis in Short-Form ATP Phosphoribosyltransferase"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New Strategies for Stereoselective Unnnatural Radical Biocatalysis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Target Class Profiling of Small Molecule Methyltransferases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biocatalysis and Synthetic Biology
7:30 pm - 8:00 pm
"Defining the Function of a Heme Enzyme in Rufomycin Biosynthesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"An Engineered Proline Hydroxylase Enables Concise Synthesis of Belzutifan"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Photoenzymatic Catalysis - Using Light to Reveal New Enzyme Functions"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Anti-Infective Biosynthesis
9:00 am - 9:30 am
"Harnessing the Chemical Potential of Unprecedented Microbes from Great Salt Lake for Antibiotic Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Crocagins - A Curious Case of Peptide-Derived Pyrroloindoline Alkaloids"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Structural Insight on Assembly-Line Catalysis in Terpene Biosynthesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Unusual Enzyme Reactions in Natural Product Biosynthesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Synthetic Natural Product Inspired Cyclic Peptides for Discovery of Bioactive Natural Products and Biocatalysts"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mapping Protein-Protein Interactions in a Multi-Component Radical SAM Enzyme"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Unraveling the Role of Lanthanides in the [Ecosystem] and the Metabolism of its Microbial Occupants"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Mechanism of Energy Transduction in Biological Nitrogen Fixation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Unconventional Iron-Dependent Enzymes in Antibiotic Biosynthesis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Principles of Enzyme Catalysis
9:00 am - 9:30 am
"Enzymology of Metalloaminopeptidases from Pseudomonas Aeruginosa "
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Targeting Selective Conformational Dynamics for Enzyme Inhibition"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"RiPP Therapy for Building a Better Backbone"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Understanding and Exploiting Thiyl Radical Cofactors."
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Surveying the Diversity of 5-Methylpyrimidine Dioxygenases and their Role in Base Modification"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"ADCA-DN-Linked Mutations Relieve Normal Autoinhibition in DNA Methyltransferase"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Artificial Bifunctional Enzymes: Antimicrobial Topological and Enzymatic Properties"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzyme Function and Engineering
7:30 pm - 8:00 pm
"The Little Protein that Could: Evolution of a Powerful Antibiotic Resistance Enzyme"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Discovery and Applications of Halogenase Chemistry"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Enzyme Fusions in Metabolic Pathways"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Emerging New Methods in Enzymology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"From Atoms to Evolution and Disease: Leveraging Microfluidics to Dissect Enzymes in High-Throughput"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Modulating Loop Dynamics and the Evolution of New Enzymes"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Discovering and Engineering New Metalloenzymes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Actinobacteria do it Differently: Surprising Features of a Mixed PDH/ODH Metabolic Supercomplex"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Chemical and Biochemical Tools to Examine the Role of Exopolysaccharides in Bacterial Biofilm Formation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Investigating and Adapting Oxidative Transformations during Cytochalasan Biosynthesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Biosynthetic Diversification of the Phosphonoalamide Natural Product Family"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Biocatalysis and Enzymology for Translational Biochemistry
7:30 pm - 8:15 pm
"Mechanistic Principles of Assembly-Line Polyketide Biosynthesis"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Enzymes and Coenzymes in the Sulfur Metabolic Pathway"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure