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Enzymes, Coenzymes and Metabolic Pathways

Gordon Research Conference

New Methods in Enzymology and Chemical Biology to Aid the Study of Mechanisms and Metabolic Pathways

July 28 - August 2, 2024

Chairs

and

Vice Chairs

and

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The Enzymes, Coenzymes and Metabolic Pathways GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2024 Gordon Research Conference on Enzymes, Coenzymes and Metabolic Pathways will highlight a broad range of topics from chemical biology, biocatalysis, mechanism and function of enzymes, to therapeutic applications in enzymology. Speakers participating at this conference will include established and emerging leaders from academia and industry to promote diverse perspectives and inspire stimulating and productive discussions. There will be opportunities for oral presentations chosen from submitted poster abstracts. This conference will afford scientists from various research areas the opportunity to explore new ideas and approaches in enzymology through stimulating scientific exchange.

Related Meeting

This GRC will be held in conjunction with the "Enzymes, Coenzymes and Metabolic Pathways" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Enzymology of Natural Products Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:15 pm	"Proteusin Peptides: Unknown Structures and Unknown Binding Modes for RiPP Biosynthesis"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:50 pm	"Biosynthetic and Functional Characterization of a Longevity Natural Product Ergothioneine on Mouse Models"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:25 pm	"Leveraging Radical Enzymology towards Synthesis of Novel Scaffolds"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Chemistry at the Membrane Discussion Leader:
9:00 am - 9:30 am	"Mechanism of Diiron Center Reduction in Stearoyl-CoA Desaturase-1"
9:30 am - 9:35 am	Discussion
9:35 am - 10:05 am	"Proteostatic Control of Cholesterol Homeostasis"
10:05 am - 10:10 am	Discussion
10:10 am - 10:35 am	Group Photo / Coffee Break
10:35 am - 11:05 am	"Orthogonal Enzyme–Substrate Design Strategy for Discovery of Human Protein Palmitoyltransferase Substrates"
11:05 am - 11:10 am	Discussion
11:10 am - 11:40 am	"Automated High Throughput Analysis of Non-Equilibrium Inhibition in Kinase Inhibitor Discovery: Case Study of ErbB Receptor Family Members"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Cryo-EM Structure of the E. coli Acetyl-CoA Carboxylase Complex, a Tube-like Filament and Reaction Chamber"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Structural Analysis of Heteromeric Multi-Subunit Acetyl-CoA Carboxylase"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Structural and Functional Analysis of the Phosphorylated BCAT Mimics"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Glycobiology Discussion Leader:
7:30 pm - 8:00 pm	"Chemoenzymatic Routes to Activated Rare Sugar Substrates of Bacterial Glycosyltransferases"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Enlisting an Endogenous Glycosidase to Study V. Cholerae Biofilm Assembly and Dispersal"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Dolichol Synthesis: From a Human Disease to Novel Twists and Required Detours"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cofactors and Metals Discussion Leader:
9:00 am - 9:30 am	"The Enzymology and Physiological Function of N-Terminal Glycine Myristoyltransferase"
9:30 am - 9:35 am	Discussion
9:35 am - 10:05 am	"The Electron Transfer and Ion Pumping Mechanisms of the Evolutionary Divergent NQR Family"
10:05 am - 10:10 am	Discussion
10:10 am - 10:35 am	Coffee Break
10:35 am - 11:05 am	"The Enzymology of a Metabolon"
11:05 am - 11:10 am	Discussion
11:10 am - 11:40 am	"Electron Transfer Bifurcation: Versatile Energy Conservation in Apparent Defiance of the Second Law of Thermodynamics"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Radical, Complicated, and yet Sophisticated: Pyranopterin Pormation in Molybdenum Cofactor Biosynthesis"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Developing a PLP-Dependent Mannichase for the Biocatalytic Synthesis of α,β-diamino Acids"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"From Indole Nitrile to Skatole Biosynthesis: A Tale of Two Diiron Enzymes"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Visualizing Biochemical Processes Discussion Leader:
7:30 pm - 8:00 pm	"Unlocking Macromolecular Dynamics with Cofactors and Small Molecules"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Real-Time Visualization of Glucose Metabolism through Multienzyme Glucosome Assemblies in Living Cells"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Visualizing and Engineering the Pikromycin Assembly Line"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Enzymology and Protein Engineering Discussion Leader:
9:00 am - 9:30 am	"Biosynthesis of Clickable Functionalities in Natural Products"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"New Tools and Strategies for Protein Engineering"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Two Oddly Complex Dehydrogenases"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Enzymatic Synthesis of Azide by a Promiscuous N-Nitrosylase"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Fluorine-Mediated Steric-Free Labeling Strategy for Cellular Substrates of Acetyltransferases and Glycosyltransferases"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Dissecting Enzyme Function with Synergistic Advances in High-Throughput Microfluidics and Genetic Code Expansion"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Combining Biosensors with Machine Learning to Improve Therapeutic Alkaloid Biosyntheses"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Emerging Areas in Enzymology Discussion Leader:
7:30 pm - 8:00 pm	"Reprogramming Translation to Read and Write Biology"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Biochemical Insight into 5-Methylpyrimidine Oxidation and Its Regulation in Bacteriophages"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Comprehensive Mutational Scan of SARS-CoV-2 Mpro Reveals Insights into Viral Resistance Mechanisms"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Nucleotide Enzymology and Biotechnology Discussion Leader:
9:00 am - 9:30 am	"Sex Chromosome-Encoded Homologous Enzymes in Sex Bias of Translation Regulation"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"mRNA Pseudouridylation by PUS7 Enhances Cellular Stress Tolerance"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Bridging the Gap: How the Radical SAM Enzyme Elp3 Uses a Unique Mechanism to Bring Together Distant Cofactors and Catalyze tRNA Modification"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Insights into the Regulatory Role of the C-Terminal Tail in Human Phosphofructokinase-1 through Molecular Simulations"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Discovery of a Gut Microbial Enzyme that Reduces Bilirubin to Urobilinogen"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Synthesis of Versatile Neuromodulatory Molecules by a Gut Microbial Glutamate Decarboxylase"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"The Distinct Catalytic, Structural, and In Vivo Features of Tumor-Driving IDH1 Mutants"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Biological Chemistry and Its Applications Discussion Leader:
7:30 pm - 8:15 pm	"From Structure–Function to Ensemble–Function: A New Paradigm for Quantitative Understanding of Protein Function"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:15 pm	"Aiming Higher: In Energy and Functional Understanding of Enzymes"
9:15 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Virginia Tech University

Anonymous Donor

Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R13AI183664. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Enzymes, Coenzymes and Metabolic Pathways (GRS)

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